CAS 108334-68-5|Syntide 2 trifluoroacetate salt

Introduction：Basic information about CAS 108334-68-5|Syntide 2 trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameSyntide 2 trifluoroacetate salt
CAS Number108334-68-5Molecular Weight1507.82000
Density1.4 g/cm3Boiling Point/
Molecular FormulaC68H122N20O18Melting Point/
MSDS/Flash Point/

Names

Namesyntide 2
SynonymMore Synonyms

Syntide 2 trifluoroacetate salt BiologicalActivity

DescriptionSyntide 2 is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 12 μM.
Related CatalogSignaling Pathways >>Neuronal Signaling >>CaMKResearch Areas >>Neurological DiseasePeptides
Target

Km: 12 μM (CaMKII)[1]

In VitroThe sequence of syntide-2 (pro-leu-ala-arg-thr-leu-ser-val-ala-gly-leu-pro-gly-lys-lys) is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the known Ca2+-dependent protein kinases for syntide-2 are determined to be as follows: protein kinase II, 100; protein kinase C, 22; phosphorylase kinase, 2; myosin light chain kinase, 0.005[1].
References

[1]. Hashimoto Y, et al. Calcium . calmodulin-dependent protein kinase II and calcium . phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide. Arch Biochem Biophys. 1987 Feb 1;252(2):418-25.

Chemical & Physical Properties

Density1.4 g/cm3
Molecular FormulaC68H122N20O18
Molecular Weight1507.82000
Exact Mass1506.92000
PSA602.34000
LogP2.04760
Index of Refraction1.629
InChIKeyNKBRRWBNPNUBDD-TYKVATLISA-N
SMILESCC(C)CC(NC(=O)C1CCCN1)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)C(C)C)C(C)O
Storage condition2~8°C

Safety Information

Hazard CodesXi
Safety Phrases22-24/25
WGK Germany3.0

Synonyms

CALMODULIN-DEPENDENT PROTEIN KINASE SUBSTRATE
CA2+/CALMODULIN KINASE II SUBSTRATE
H-PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-ALA-GLY-LEU-PRO-GLY-LYS-LYS-OH
PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-ALA-GLY-LEU-PRO-GLY-LYS-LYS
PRO-LEU-ALA-ARG-THR-LEU-SER-VAL-GLY-LEU-PRO-GLY-LYS-LYS
SYNTIDE-2 [PLARTLSVAGLPGKK]
Syntide2calmodulin-dependentproteinkinase
PLARTLSVAGLPGKK
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