CAS 16875-11-9|Bradykinin Fragment 2-9
| Common Name | Bradykinin Fragment 2-9 | ||
|---|---|---|---|
| CAS Number | 16875-11-9 | Molecular Weight | 904.02300 |
| Density | 1.47g/cm3 | Boiling Point | / |
| Molecular Formula | C44H61N11O10 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 5-(diaminomethylideneamino)-2-[[2-[[1-[3-hydroxy-2-[[3-phenyl-2-[[2-[[1-(pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl]amino]acetyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]pentanoic acid |
|---|---|
| Synonym | More Synonyms |
Bradykinin Fragment 2-9 BiologicalActivity
| Description | Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Bradykinin ReceptorResearch Areas >>Cardiovascular DiseasePeptides |
| In Vitro | The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1]. |
| References | [1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65. |
Chemical & Physical Properties
| Density | 1.47g/cm3 |
|---|---|
| Molecular Formula | C44H61N11O10 |
| Molecular Weight | 904.02300 |
| Exact Mass | 903.46000 |
| PSA | 317.58000 |
| LogP | 0.95140 |
| Index of Refraction | 1.684 |
| InChIKey | ZZHVXIPXTCBVBE-UHFFFAOYSA-N |
| SMILES | NC(N)=NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C1CCCN1C(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1)C(=O)O |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F+ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
Articles9
More Articles| Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells. Am. J. Physiol. Cell Physiol. 303(12) , C1260-8, (2012) In this study, the interaction of natriuretic peptides (NP) and bradykinin (BK) signaling pathways was identified by measuring membrane potential (V(m)) and intracellular Ca(2+) using the patch-clamp ... | |
| Accurate mass measurements using MALDI-TOF with delayed extraction. J. Protein Chem. 16(5) , 363-9, (1997) Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is now an essential tool in biopolymer analysis. Sensitivity and mass range are unsurpassed, but mass measureme... | |
| Shattering of Peptide ions on self-assembled monolayer surfaces. J. Am. Chem. Soc. 125(6) , 1625-32, (2003) Time- and collision energy-resolved surface-induced dissociation (SID) of des-Arg(1)- and des-Arg(9)-bradykinin on a fluorinated self-assembled monolayer (SAM) surface was studied by use of a novel Fo... |
Synonyms
| L-Phe-L-Trp-OH |
| H-PPGFSPFR-OH |
| bradykinin fragment 2-9 |
| n-l-phenylalanyl-l-tryptopha |
| L-PHENYLALANYL-L-TRYPTOPHAN |
| Phe-Trp-OH |
| des-[Arg1]-bradykinin |
| phenylalanyltryptophane |
| des-Arg9-bradykinin |
| phenylalanyltryptophan |
| Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg |
| Bradykinin (2-9) |
