CAS 1320288-17-2|UNC0646

Introduction：Basic information about CAS 1320288-17-2|UNC0646, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. UNC0646 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	UNC0646
CAS Number	1320288-17-2	Molecular Weight	621.899
Density	1.1±0.1 g/cm3	Boiling Point	754.6±70.0 °C at 760 mmHg
Molecular Formula	C₃₆H₅₉N₇O₂	Melting Point	/
MSDS	USA	Flash Point	410.1±35.7 °C

Names

Name	N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
Synonym	More Synonyms

UNC0646 BiologicalActivity

Description	UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM.IC50 value: 6 nM [1]Target: G9aUNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.
Related Catalog	Signaling Pathways >>Epigenetics >>Histone MethyltransferaseResearch Areas >>Cancer
References	[1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	754.6±70.0 °C at 760 mmHg
Molecular Formula	C₃₆H₅₉N₇O₂
Molecular Weight	621.899
Flash Point	410.1±35.7 °C
Exact Mass	621.473022
PSA	72.46000
LogP	5.75
Vapour Pressure	0.0±2.5 mmHg at 25°C
Index of Refraction	1.587
Storage condition	2-8℃

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

Benzenemethanamine,N-(1-cyclohexylethylidene)

N-(1-cyclohexylethylidene)benzylamine

UNC0646

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