Introduction：Basic information about CAS 163706-36-3|Cangrelor tetrasodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cangrelor tetrasodium |
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| CAS Number | 163706-36-3 | Molecular Weight | 864.286 |
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| Density | / | Boiling Point | 979ºC at 760 mmHg |
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| Molecular Formula | C17H21Cl2F3N5Na4O12P3S2 | Melting Point | / |
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| MSDS | / | Flash Point | 545.9ºC |
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Names
| Name | tetrasodium,[dichloro(phosphonato)methyl]-[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-oxidophosphoryl]oxyphosphinate |
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| Synonym | More Synonyms |
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Cangrelor tetrasodium BiologicalActivity
| Description | Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist[1][2]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>P2Y ReceptorResearch Areas >>Inflammation/Immunology |
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| In Vitro | Cangrelor tetrasodium is the only potent intravenous direct and specific adenosine diphosphate (ADP) P2Y12 receptor antagonist[1]. Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor[3]. |
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| In Vivo | Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2]. |
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| References | [1]. Bhattad VB, , et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408. [2]. Zhan T, Wei T, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83-92. [3]. Bekő K, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain. J Thromb Haemost. 2017;15(6):1223-1235. |
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Chemical & Physical Properties
| Boiling Point | 979ºC at 760 mmHg |
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| Molecular Formula | C17H21Cl2F3N5Na4O12P3S2 |
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| Molecular Weight | 864.286 |
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| Flash Point | 545.9ºC |
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| Exact Mass | 862.876099 |
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| PSA | 347.26000 |
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| LogP | 4.67630 |
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| Vapour Pressure | 0mmHg at 25°C |
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| InChIKey | COWWROCHWNGJHQ-OPKBHZIBSA-J |
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| SMILES | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2C1OC(COP(=O)([O-])OP(=O)([O-])C(Cl)(Cl)P(=O)([O-])[O-])C(O)C1O.[Na+].[Na+].[Na+].[Na+] |
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| Storage condition | -20℃ |
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Synonyms
| Tetrasodium 5'-O-[({[dichloro(phosphonato)methyl]phosphinato}oxy)phosphinato]-N-[2-(methylsulfanyl)ethyl]-2-[(3,3,3-trifluoropropyl)sulfanyl]adenosine |
| Cangrelor tetrasodium |
| Adenosine, 5'-O-[[[(dichlorophosphonomethyl)hydroxyphosphinyl]oxy]hydroxyphosphinyl]-N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, sodium salt (1:4) |
| UNII-2144G00Y7W |
| Cangrelor tetrasodium (USAN) |
