Introduction：Basic information about CAS 1699-51-0|DL-LAUDANOSINE, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | DL-LAUDANOSINE |
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| CAS Number | 1699-51-0 | Molecular Weight | 357.44300 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H27NO4 | Melting Point | 115℃ |
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| MSDS | / | Flash Point | / |
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| Symbol |
GHS06 | Signal Word | Danger |
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Names
| Name | dl-laudanosine |
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| Synonym | More Synonyms |
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DL-LAUDANOSINE BiologicalActivity
| Description | DL-Laudanosine, an Atracurium and Cisatracurium metabolite, crosses the blood–brain barrier and may cause excitement and seizure activity[1]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| In Vivo | DL-Laudanosine (Laudanosine) appears to be unique in its ability to produce cerebral stimulation in lightly anaesthetized animals and it is reported to cause arousal from anaesthesia in subconvulsive doses[1]. Animal Model: Male CFLP mice weighing 18-25 g, and male Wistar rats weighing 120-150 g [2]. Dosage: 10-20 mg/kg. Administration: IV. Result: Caused convulsions and hind limb extensions. |
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| References | [1]. V Fodale, et al. Laudanosine, an Atracurium and Cisatracurium Metabolite. Eur J Anaesthesiol. 2002 Jul;19(7):466-73. [2]. D J Chapple, et al. Cardiovascular and Neurological Effects of Laudanosine. Studies in Mice and Rats, and in Conscious and Anaesthetized Dogs. Br J Anaesth. 1987 Feb;59(2):218-25. |
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Chemical & Physical Properties
| Melting Point | 115℃ |
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| Molecular Formula | C21H27NO4 |
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| Molecular Weight | 357.44300 |
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| Exact Mass | 357.19400 |
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| PSA | 40.16000 |
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| LogP | 3.43060 |
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| InChIKey | KGPAYJZAMGEDIQ-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CC2c3cc(OC)c(OC)cc3CCN2C)cc1OC |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NX5070000
- CHEMICAL NAME :
- Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratryl- , (+-)-
- CAS REGISTRY NUMBER :
- 1699-51-0
- LAST UPDATED :
- 198209
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H27-N-O4
- MOLECULAR WEIGHT :
- 357.49
- WISWESSER LINE NOTATION :
- T66 CNT&J B1R CO1 DO1& C1 HO1 IO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 47 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 20,894,1977
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H301 + H311 + H331 |
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| Precautionary Statements | Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233 |
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| Risk Phrases | 26/28-40 |
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| Safety Phrases | 22-24/25 |
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| RIDADR | UN 2810 |
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| HS Code | 2933499090 |
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Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (R)-Laudanosine |
| LAUDANOSINE,DL-(SH) |
| (+/-)-LAUDANOSIDE |
| (+-)-laudanosine |
| LAUDANOSINE,DL-(SH)(CALL) |
| LAUDANOSINE,DL |
| DL-LAUDANOSIDE |
