Introduction：Basic information about CAS 139339-45-0|Ro 24-7429, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ro 24-7429 |
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| CAS Number | 139339-45-0 | Molecular Weight | 272.73300 |
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| Density | 1.36g/cm3 | Boiling Point | 514.6°C(760mmHg),计算值 |
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| Molecular Formula | C14H13ClN4 | Melting Point | / |
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| MSDS | / | Flash Point | 265°C |
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Names
| Name | 7-Chloro-N-Methyl-5-(1H-Pyrrol-2-Yl)-3H-1,4-Benzodiazepin-2-Amine |
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| Synonym | More Synonyms |
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Ro 24-7429 BiologicalActivity
| Description | Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Anti-infection >>HIVResearch Areas >>InfectionResearch Areas >>Inflammation/Immunology |
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| In Vitro | Ro 24-7429 (0.1-5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[1]. Ro 24-7429 (1-25 μM) also induces apoptosis and inhibits antigen-induced lymphocyte proliferation[1]. Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[2]. Apoptosis Analysis[1] Cell Line: Peripheral blood mononuclear cells (PBMCs) Concentration: 0.1 μM, 1 μM, 5 μM Incubation Time: 3 days Result: Induced a dose-dependent increase in apoptosis of cultured PBMCs. |
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| In Vivo | Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs[2]. Animal Model: C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin[2] Dosage: 17.5 mg/kg, 35 mg/kg, and 70 mg/kg Administration: i.p.; daily; for 14 or 21 days Result: Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model. |
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| References | [1]. A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6. [2]. Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208. |
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Chemical & Physical Properties
| Density | 1.36g/cm3 |
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| Boiling Point | 514.6°C(760mmHg),计算值 |
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| Molecular Formula | C14H13ClN4 |
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| Molecular Weight | 272.73300 |
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| Flash Point | 265°C |
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| Exact Mass | 272.08300 |
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| PSA | 52.54000 |
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| LogP | 2.03060 |
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Synonyms
| Ro 24-7429 |
| Aids003055 |
| [7-Chloro-5-(1H-Pyrrol-2-Yl)-3H-1,4-Benzodiazepin-2-Yl]-Methyl-Amine |
| Aids-003055 |
