CAS 138-86-3|limonene

Introduction：Basic information about CAS 138-86-3|limonene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. limonene BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles78
8. Synonyms

Common Name	limonene
CAS Number	138-86-3	Molecular Weight	136.234
Density	0.8±0.1 g/cm3	Boiling Point	175.4±20.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₆	Melting Point	-84--104 °C
MSDS	ChineseUSA	Flash Point	42.8±0.0 °C
Symbol	GHS02, GHS07, GHS09	Signal Word	Warning

Names

Name	limonene
Synonym	More Synonyms

limonene BiologicalActivity

Description	Limonene is a monoterpene in citrus peel oil. A popular disinfectant and food preservative. Antimicrobial activities[1]. Anti-proliferative activities[2]. Antioxidant and anti-inflammatory effect[3].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologyResearch Areas >>InfectionNatural Products >>Terpenoids and Glycosides
Target	Bacterial[1]
In Vitro	Acute toxicity to limonene is largely due to the common oxidation product limonene-hydroperoxide. The mutant protein AhpCL177Q 35 is able to alleviate this toxicity by reducing the hydroperoxide to a more benign compound[1]. Limonene exerts anti-proliferative action on a lymphoma cell line without modifying normal lymphocyte viability[2].
In Vivo	Limonene (50-100 mg/kg) exerts gastroprotection through local mucosal defense mechanisms, such as increasing the mucus production, modulation of the oxidative stress and inflammatory response and inhibition of Nf-κb expression[3].
References	[1]. Chubukov V, et al. Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC. Appl Environ Microbiol. 2015 Jul;81(14):4690-6. [2]. Roberto D, et al. Antioxidant activity of limonene on normal murine lymphocytes: relation to H2O2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010 Jan;106(1):38-44. [3]. de Souza MC, et al. Gastroprotective effect of limonene in rats: Influence on oxidative stress, inflammation and gene expression. Phytomedicine. 2018 Sep 4;53:37-42.

Chemical & Physical Properties

Density	0.8±0.1 g/cm3
Boiling Point	175.4±20.0 °C at 760 mmHg
Melting Point	-84--104 °C
Molecular Formula	C₁₀H₁₆
Molecular Weight	136.234
Flash Point	42.8±0.0 °C
Exact Mass	136.125198
LogP	4.45
Vapour density	4.7 (vs air)
Vapour Pressure	1.5±0.2 mmHg at 25°C
Index of Refraction	1.468
InChIKey	XMGQYMWWDOXHJM-UHFFFAOYSA-N
SMILES	C=C(C)C1CC=C(C)CC1
Stability	Stable. Flammable. Incompatible with strong oxidizing agents.
Water Solubility	<1 g/100mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OS8100000

CHEMICAL NAME :: p-Mentha-1,8-diene

CAS REGISTRY NUMBER :: 138-86-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C10-H16

MOLECULAR WEIGHT :: 136.26

WISWESSER LINE NOTATION :: L6UTJ A1 DY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 12,703,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5550 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 24,700,1989

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987- Volume(issue)/page/year: 113,47,1990 *** REVIEWS *** TOXICOLOGY REVIEW ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7. Volume(issue)/page/year: 78,99,1972 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1342 No. of Facilities: 3959 (estimated) No. of Industries: 70 No. of Occupations: 60 No. of Employees: 45463 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1342 No. of Facilities: 12642 (estimated) No. of Industries: 103 No. of Occupations: 90 No. of Employees: 185336 (estimated) No. of Female Employees: 45650 (estimated)

Safety Information

Symbol	GHS02, GHS07, GHS09
Signal Word	Warning
Hazard Statements	H226-H315-H317-H410
Precautionary Statements	P273-P280-P501
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;N:Dangerousfortheenvironment;
Risk Phrases	R10;R38;R43;R50/53
Safety Phrases	S24-S37-S60-S61
RIDADR	UN 2052 3/PG 3
WGK Germany	2
RTECS	OS8350000
Packaging Group	III
Hazard Class	3
HS Code	2942000000

Customs

HS Code	2942000000

Articles78

Materials recovery from waste liquid crystal displays: A focus on indium.

Waste Manag. 45 , 325-33, (2015)

In the present work the recovery of indium and of the polarizing film from waste liquid crystal displays was experimentally investigated in the laboratory. First of all, the polarizing film was remove...

Capturing of the monoterpene olefin limonene produced in Saccharomyces cerevisiae.

Yeast , doi:10.1002/yea.3038, (2014)

Monoterpene olefins such as limonene are plant compounds with applications as flavouring and fragrance agents, as solvents and potentially also in polymer and fuel chemistry. We engineered baker's yea...

Carbopol 934, 940 and Ultrez 10 as viscosity modifiers of palm olein esters based nano-scaled emulsion containing ibuprofen.

Pak. J. Pharm. Sci. 26(1) , 75-83, (2013)

Micro-emulsions and sometimes nano-emulsions are well known candidates to deliver drugs locally. However, the poor rheological properties are marginally affecting their acceptance pharmaceutically. Th...

Synonyms

Cyclohexene, 4-Isopropenyl-1-methyl-

EINECS 227-815-6

p-mentha-1,8-diene

(±)-p-Mentha-1,8-diene

Mentha-1,8-diene, DL

4-(1-methylethenyl)-1-methyl-cyclohexene

Methyl-4-isopropenyl-1-cyclohexene

Limonene, dl-

Methyl-4-isopropenylcyclohexene

(±)-Limonene

Cyclohexene, 1-methyl-4-(1-methylethenyl)-

Dipanol

DL-p-mentha-1,8-diene

p-Mentha-1,8-diene, (±)-

Methyl-4-(1-methylethenyl)cyclohexene

Unitene

(±)-(RS)-limonene

Depanol

a-limonene

p-menth-1,8-diene

Nesol

MFCD00001558

1-Methyl-4-methylethenylcyclohexene

Mentha-1,8-diene

α-Limonene

Cinen

Eulimen

limonene, (±)-isomer

4-Isopropenyl-1-methylcyclohexene

dycom

Ciene

Limonene

Limonene, (±)-

Cinene

1,8-p-Mentadiene

1-methyl-4-(prop-1-en-2-yl)cyclohexene

p-Mentha-1,8-diene, DL-

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