CAS 3687-18-1|Tramiprosate

Introduction：Basic information about CAS 3687-18-1|Tramiprosate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tramiprosate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles35
7. Synonyms

Common Name	Tramiprosate
CAS Number	3687-18-1	Molecular Weight	139.173
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₃H₉NO₃S	Melting Point	293 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07	Signal Word	Warning

Names

Name	3-Amino-1-propanesulfonic acid
Synonym	More Synonyms

Tramiprosate BiologicalActivity

Description	Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg.
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Amyloid-βResearch Areas >>Cancer
References	[1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17. [2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11.

Description

Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg.

Related Catalog

Signaling Pathways >>Neuronal Signaling >>Amyloid-βResearch Areas >>Cancer

References

[1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.

[2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Melting Point	293 °C (dec.)(lit.)
Molecular Formula	C₃H₉NO₃S
Molecular Weight	139.173
Exact Mass	139.030319
PSA	88.77000
LogP	-2.25
Index of Refraction	1.508
InChIKey	SNKZJIOFVMKAOJ-UHFFFAOYSA-N
SMILES	NCCCS(=O)(=O)O
Storage condition	Store at 0-5°C

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	1
HS Code	2921199090

Customs

HS Code	2921199090
Summary	2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles35

Altering in vivo macrophage responses with modified polymer properties.

Biomaterials 56 , 187-97, (2015)

Macrophage reprogramming has long been the focus of research in disease therapeutics and biomaterial implantation. With different chemical and physical properties of materials playing a role in macrop...

Phospho-iTRAQ: assessing isobaric labels for the large-scale study of phosphopeptide stoichiometry.

J. Proteome Res. 14(2) , 839-49, (2015)

The ability to distinguish between phosphopeptides of high and low stoichiometry is essential to discover the true extent of protein phosphorylation. We here extend the strategy whereby a peptide samp...

Effect of bore fluid composition on microstructure and performance of a microporous hollow fibre membrane as a cation-exchange substrate.

J. Chromatogr. A. 1394 , 148-53, (2015)

Micro-capillary film (MCF) membranes are effective platforms for bioseparations and viable alternatives to established packed bed and membrane substrates at the analytical and preparative chromatograp...

Synonyms

1-Propanesulfonic acid, 3-amino-

tramiprosate

Homotaurine

3-aminopropane-1-sulfonic acid

Alzhemed

3-Aminopropane sulfonic acid

3-Amino-1-propanesulfonic acid

3-aminopropane-1-sulphonic acid

3-Amino-propane-1-sulfonic acid

3-APS

EINECS 222-977-4

MFCD00008225

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