CAS 134-63-4|α-Lobeline Hydrochcloride
Introduction：Basic information about CAS 134-63-4|α-Lobeline Hydrochcloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | α-Lobeline Hydrochcloride | ||
|---|---|---|---|
| CAS Number | 134-63-4 | Molecular Weight | 373.916 |
| Density | / | Boiling Point | 485.6ºC at 760mmHg |
| Molecular Formula | C22H28ClNO2 | Melting Point | 183-185 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 247.5ºC |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | α-Lobeline Hydrochcloride |
|---|---|
| Synonym | More Synonyms |
α-Lobeline Hydrochcloride BiologicalActivity
| Description | Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological DiseaseNatural Products >>Alkaloid |
Chemical & Physical Properties
| Boiling Point | 485.6ºC at 760mmHg |
|---|---|
| Melting Point | 183-185 °C (dec.)(lit.) |
| Molecular Formula | C22H28ClNO2 |
| Molecular Weight | 373.916 |
| Flash Point | 247.5ºC |
| Exact Mass | 373.180847 |
| PSA | 40.54000 |
| LogP | 4.97590 |
| Vapour Pressure | 3.02E-11mmHg at 25°C |
| Index of Refraction | -57.5 ° (C=1, H2O) |
| InChIKey | MKMYPTLXLWOUSO-HWAJWLCKSA-N |
| SMILES | CN1C(CC(=O)c2ccccc2)CCCC1CC(O)c1ccccc1.Cl |
| Storage condition | Store at RT |
| Water Solubility | H2O: 25 mg/mL |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 87500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,913,1982
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 163,279,1931
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H331 |
| Precautionary Statements | P261-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R23/25 |
| Safety Phrases | S36/37/39-S45 |
| RIDADR | UN 1544 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | OJ8490100 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
Articles3
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| The effects of lobeline on nicotine withdrawal-induced depression-like behavior in mice. Psychopharmacol. Ser. 231(15) , 2989-98, (2014) Evidence suggests that neuronal nicotinic acetylcholine receptor (nAChR) ligand lobeline has antidepressant-like properties.The present study investigated the effects of lobeline on nicotine withdrawa... |
Synonyms
| Ethanone, 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-, hydrochloride (1:1) |
| 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride (1:1) |
| Lobelin hydrochloride |
| Lobeline hydrochloride |
| EINECS 205-150-2 |
| 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride |
| 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride (1:1) |
| MFCD00082455 |
| Ethanone, 2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, hydrochloride |
| Ethanone, 2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, hydrochloride (1:1) |
| 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone hydrochloride (1:1) |
| 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanonhydrochlorid |
| α-Lobeline hydrochloride |
| (-)-Lobeline hydrochloride |
| 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phényléthyl]-1-méthyl-2-pipéridinyl}-1-phényléthanone chlorhydrate |
| 2-(6-(2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride |
| Lobeline (hydrochloride) |
