CAS 25905-77-5|Minaprine
| Common Name | Minaprine | ||
|---|---|---|---|
| CAS Number | 25905-77-5 | Molecular Weight | 298.38 |
| Density | 1.156g/cm3 | Boiling Point | 531.2ºC at 760 mmHg |
| Molecular Formula | C17H22N4O | Melting Point | 122° |
| MSDS | ChineseUSA | Flash Point | 275.1ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | minaprine |
|---|---|
| Synonym | More Synonyms |
Minaprine BiologicalActivity
| Description | Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
| References | [1]. Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8. [2]. Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41. |
Chemical & Physical Properties
| Density | 1.156g/cm3 |
|---|---|
| Boiling Point | 531.2ºC at 760 mmHg |
| Melting Point | 122° |
| Molecular Formula | C17H22N4O |
| Molecular Weight | 298.38 |
| Flash Point | 275.1ºC |
| PSA | 50.28000 |
| LogP | 3.81100 |
| Vapour Pressure | 2.29E-11mmHg at 25°C |
| Index of Refraction | 1.595 |
| InChIKey | LDMWSLGGVTVJPG-UHFFFAOYSA-N |
| SMILES | Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1 |
| Storage condition | -20℃ |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | QE3477830 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles25
More Articles| Multicentric double-blind study comparing efficacy and safety of minaprine and imipramine in dysthymic disorders. Neuropsychobiology 31(2) , 68-75, (1995) This multicentre study compares the therapeutic efficacy and safety of minaprine (200 mg) to that of imipramine (50, 75, 100 mg) in the treatment of patients over 40 years suffering from dysthymic dis... | |
| Computerised psychomotor performance testing: a comparative study of the single dose pharmacodynamics of minaprine and amitriptyline in young and elderly subjects. Br. J. Clin. Pharmacol. 36(4) , 376-9, (1993) The psychomotor and cardiovascular effects of minaprine 100 mg, a novel antidepressant, were compared with amitriptyline 25 mg, as a positive control, and placebo in a single dose randomised double-bl... | |
| Cholinomimetic activity of minaprine is related to the amelioration of delayed neuronal death in gerbils. Physiol. Behav. 52(1) , 141-7, (1992) We attempted to determine if the cholinomimetic activity of the psychotropic drug minaprine was related to the amelioration of the delayed neuronal death induced by cerebral ischemia in Mongolian gerb... |
Synonyms
| TS-370 |
| Minaprin diHCl |
| MINAPRIN DIHYDROCHLORIDE |
| MINAPRINE HYDROCHLORIDE |
| MINAPRINE DIHYDROCHLORIDE |
| minaprin |
