CAS 161600-01-7|netoglitazone
| Common Name | netoglitazone | ||
|---|---|---|---|
| CAS Number | 161600-01-7 | Molecular Weight | 381.420 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 599.5±30.0 °C at 760 mmHg |
| Molecular Formula | C21H16FNO3S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 316.4±24.6 °C |
| Symbol | GHS09 | Signal Word | Warning |
Names
| Name | 5-[[6-[(2-fluorophenyl)methoxy]naphthalen-2-yl]methyl]-1,3-thiazolidine-2,4-dione |
|---|---|
| Synonym | More Synonyms |
netoglitazone BiologicalActivity
| Description | Netoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>PPARResearch Areas >>Metabolic Disease |
| Target | PPARα PPARγ |
| References | [1]. Reginato MJ, et al. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. J Biol Chem. 1998 Dec 4;273(49):32679-84. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 599.5±30.0 °C at 760 mmHg |
| Molecular Formula | C21H16FNO3S |
| Molecular Weight | 381.420 |
| Flash Point | 316.4±24.6 °C |
| Exact Mass | 381.083496 |
| PSA | 80.70000 |
| LogP | 4.50 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.668 |
| InChIKey | PKWDZWYVIHVNKS-UHFFFAOYSA-N |
| SMILES | O=C1NC(=O)C(Cc2ccc3cc(OCc4ccccc4F)ccc3c2)S1 |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P501 |
| Hazard Codes | N |
| Risk Phrases | 50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| RTECS | XJ5813445 |
Articles19
More Articles| MCC-555-induced NAG-1 expression is mediated in part by KLF4. Eur. J. Pharmacol. 637(1-3) , 30-7, (2010) Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a central role in cell differentiation, metabolism and tumorigenesis. We have investigated the therapeutic properties of 5-[[6-[(2-fl... | |
| Chronic treatment with the thiazolidinedione, MCC-555, is associated with reductions in nitric oxide synthase activity and beta-cell apoptosis in the pancreas of the Zucker Diabetic Fatty rat. Int. J. Exp. Pathol. 84(2) , 83-9, (2003) The Zucker Diabetic Fatty (ZDF) rat is a model of impaired insulin sensitivity arising from hyperphagia owing to a mutation in the leptin receptor. In time, young ZDF rats, which are not initially dia... | |
| Activation of PPARgamma is not involved in butyrate-induced epithelial cell differentiation. Exp. Cell Res. 310(1) , 196-204, (2005) Histone deacetylase-inhibitors affect growth and differentiation of intestinal epithelial cells by inducing expression of several transcription factors, e.g. Peroxisome proliferator-activated receptor... |
Synonyms
| 5-({6-[(2-Fluorobenzyl)oxy]-2-naphthyl}methyl)-1,3-thiazolidine-2,4-dione |
| 2,4-Thiazolidinedione, 5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]- |
| UNII-QOV2JZ647A |
| Isaglitazone |
| 5-({6-[(2-fluorobenzyl)oxy]naphthalen-2-yl}methyl)-1,3-thiazolidine-2,4-dione |
| MCC-555 |
| netoglitazone |
