CAS 130018-87-0|Levocetirizine dihydrochloride
Introduction：Basic information about CAS 130018-87-0|Levocetirizine dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Levocetirizine dihydrochloride | ||
|---|---|---|---|
| CAS Number | 130018-87-0 | Molecular Weight | 461.810 |
| Density | / | Boiling Point | 542.1ºC at 760 mmHg |
| Molecular Formula | C21H27Cl3N2O3 | Melting Point | 215-220ºC |
| MSDS | ChineseUSA | Flash Point | 281.6ºC |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | Levocetirizine Dihydrochloride |
|---|---|
| Synonym | More Synonyms |
Levocetirizine dihydrochloride BiologicalActivity
| Description | Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>EndocrinologyResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
| In Vivo | Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats[1]. Animal Model: 30 male Sprague-Dawley rats (8 weeks old; 200-250 g)[1] Dosage: 0.4 mg/kg Administration: Oral administration (Pharmacokinetic Analysis) Result: The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively. |
| References | [1]. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672. |
Chemical & Physical Properties
| Boiling Point | 542.1ºC at 760 mmHg |
|---|---|
| Melting Point | 215-220ºC |
| Molecular Formula | C21H27Cl3N2O3 |
| Molecular Weight | 461.810 |
| Flash Point | 281.6ºC |
| Exact Mass | 460.108734 |
| PSA | 53.01000 |
| LogP | 4.62800 |
| InChIKey | PGLIUCLTXOYQMV-GHVWMZMZSA-N |
| SMILES | Cl.Cl.O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 |
| Storage condition | room temp |
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| Hazard Codes | Xn,N |
| Risk Phrases | 22-50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| HS Code | 2933990090 |
Customs
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles2
More Articles| Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 117 , 380-9, (2015) A method for fast chiral separation of cetirizine and quantitation of levocetirizine in human plasma using subcritical fluid chromatography with tandem mass spectrometry was developed and validated. T... | |
| Development and characterization of pharmacokinetic parameters of fast-dissolving films containing levocetirizine. Sci. Pharm. 80 , 779-87, (2012) A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content o... |
Synonyms
| Xyzall |
| EINECS 200-659-6 |
| (R)-Cetirizine Dihydrochloride |
| Levocetirizine dihydrochloride |
| (2-{4-[(R)-(4-Chlorphenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)essigsäuredihydrochlorid |
| MFCD07366507 |
| (-)-Cetirizine dihydrochloride |
| Levocetirizine 2HCl |
| Xusal |
| (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid dihydrochloride |
| 2-[2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]acetic Acid Dihydrochloride |
| Xyzal |
| acide (2-{4-[(R)-(4-chlorophényl)(phényl)méthyl]pipérazin-1-yl}éthoxy)acétique dichlorhydrate |
| acetic acid, [2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride |
| Acetic acid, 2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, hydrochloride (1:2) |
| (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride |
