CAS 130-37-0|Menadione sodiuM bisulfite
Introduction：Basic information about CAS 130-37-0|Menadione sodiuM bisulfite, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Menadione sodiuM bisulfite | ||
|---|---|---|---|
| CAS Number | 130-37-0 | Molecular Weight | 276.241 |
| Density | / | Boiling Point | / |
| Molecular Formula | C11H9NaO5S | Melting Point | 121-124ºC |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07, GHS09 | Signal Word | Warning |
Names
| Name | menadione sodium sulfonate |
|---|---|
| Synonym | More Synonyms |
Menadione sodiuM bisulfite BiologicalActivity
| Description | Menadione bisulfite (sodium) is used as an agent to induce acute oxidative stress, and to function as a plant-defense activator against several pathogens. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Infection |
| In Vitro | Menadione sodium bisulfite (500 μM) treatment and the concomitant ROS increase have an important impact on the photosynthetic activity of the cells. Global and specific antioxidant defences decrease with Menadione sodium bisulfite (500 μM) treatment[1]. Menadione sodium bisulfite and PABA activate similar defense responses (PR, ROS, and HR). Menadione sodium bisulfite enhances resistance, both locally and systemically, to phoma stem canker disease caused by Leptosphaeria maculans. Menadione sodium bisulfite treatment induces resistance against downy mildew in pearl millet. Menadione sodium bisulfite acts through priming of specific sets of the plant innate-defense repertoire. Menadione sodium bisulfite treatment up-regulates the expression of a gene encoding a GRX480 protein, a member of the glutaredoxin family that regulates protein redox state[1]. |
| Kinase Assay | Briefly, cells are lysed by sonication (6 cycles of 10 s separated by 30 s, on ice) in a buffer containing 25 mM Hepes at pH 7.5, 5 mM MgCl2, 5 mM DTT, 2 mM PMSF, 5 mM EDTA, 400 mM sorbitol and 10 μg/mL Protease Inhibitor cocktail. A quantity of 40 μg Symbiodinium protein extract is incubated in the reaction buffer. The mixture consists of 50 μM Ac-DEVD-AFC, 100 mM Hepes at pH 7.5, 10% (v/v) sucrose, 0.1% (v/v) CHAPS, 10 mM DTT and 10 mM PMSF. Samples are then incubated in black 96-well microplates and the fluorescence emitted is measured every 3 min for 90 min at 505 nm, with a 400 nm excitation wavelength provided by a FLX-Xenius spectrofluorometer. Caspase-like activities are then expressed in pmol of AFC cleavage per minute and illustrated as percentage of the controls. |
| References | [1]. Roberty S, et al. Differential antioxidant response between two Symbiodinium species from contrasting environments. Plant Cell Environ. 2016 Dec;39(12):2713-2724. |
Chemical & Physical Properties
| Melting Point | 121-124ºC |
|---|---|
| Molecular Formula | C11H9NaO5S |
| Molecular Weight | 276.241 |
| Exact Mass | 276.006836 |
| PSA | 99.72000 |
| LogP | 1.84040 |
| InChIKey | XDPFHGWVCTXHDX-UHFFFAOYSA-M |
| SMILES | CC1(S(=O)(=O)[O-])CC(=O)c2ccccc2C1=O.[Na+] |
| Storage condition | −20°C |
| Water Solubility | H2O: ≥50mg/mL, clear, colorless to faintly yellow |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg/9D-I
- TOXIC EFFECTS :
- Cardiac - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 25 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 41,1283,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84777 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 705 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84777 No. of Facilities: 524 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2658 (estimated)
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 25 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 41,1283,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84777 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 705 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84777 No. of Facilities: 524 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 2658 (estimated)
Safety Information
| Symbol | GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H410 |
| Precautionary Statements | P273-P305 + P351 + P338-P501 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36 |
| Safety Phrases | S26 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| Hazard Class | 9.0 |
| HS Code | 2914700090 |
Customs
| HS Code | 2914399090 |
|---|---|
| Summary | 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| hemodal |
| menadione sodium bisulfite |
| sodium 2-methyl-1,2,3,4-tetrahydronaphthalene-1,4-dione-2-sulfonate |
| kawitan |
| golagenk |
| kavitan |
| UNII:97K34V88SA |
| msbc |
| 2-Methyl-1,4-naphthoquinone sodium bisulfite |
| EINECS 204-987-0 |
| Sodium 1,2,3,4-Tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonate |
| sodium 2-methyl-1,4-dioxo-1,2,3,4-tetrahydronaphthalene-2-sulfonate |
| Sodium 2-methyl-1,4-dioxo-1,2,3,4-tetrahydro-2-naphthalenesulfonate |
| MENADIONE SODIUM SULFONATE |
| kalzon |
| ido-k |
| MFCD00051456 |
| 2-Naphthalenesulfonic acid, 1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-, sodium salt (1:1) |
| bisulfite sodique de menadione |
| klotogen |
| hykinone |
| vikasol |
| hemoklot |
| menadioni natrii bisulfis |
| bisulfito sodico de menadiona |
