Introduction：Basic information about CAS 131123-76-7|5,7-Dichlorokynurenic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 5,7-Dichlorokynurenic acid |
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| CAS Number | 131123-76-7 | Molecular Weight | 258.05800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C10H5Cl2NO3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 5,7-dichlorokynurenic acid sodium salt |
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| Synonym | More Synonyms |
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5,7-Dichlorokynurenic acid BiologicalActivity
| Description | 5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine site on NMDA receptor with a KB of 65 nM. 5,7-Dichlorokynurenic acid, a derivative of kynurenic acid, reduced NMDA-induced neuron injury in rat cortical cell cultures[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| References | [1]. D McNamara, et al. 5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120(1):17-20. |
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Chemical & Physical Properties
| Molecular Formula | C10H5Cl2NO3 |
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| Molecular Weight | 258.05800 |
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| Exact Mass | 256.96500 |
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| PSA | 70.42000 |
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| LogP | 2.94540 |
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| Appearance of Characters | solid | light yellow |
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| InChIKey | BGKFPRIGXAVYNX-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1cc(=O)c2c(Cl)cc(Cl)cc2[nH]1 |
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| Storage condition | Desiccate at RT |
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| Water Solubility | 0.1 M NaOH: soluble |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36 |
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| WGK Germany | 3 |
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| HS Code | 2933499090 |
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Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 5,7-DICHLOROKYNURENIC ACID |
| 5,7-Dichlorokynurenic acid sodium salt |
| 5,7-Dichorokynurenic acid |
| 5,7-dichloro-4-hydroxy-2-carboxyquinoline |
| MFCD00674925 |
| 5,7-DCKA |
| 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID |
| 5,7-Dichloro-4-hydroxy-2-quinolinecarboxylic acid |
| 5,7-DICHLOROKYNURENIC ACID POTENT EXCITA TORY AMI |
| 2-Quinolinecarboxylic acid,5,7-dichloro-4-hydroxy |
| 5,7-dichlorokynurenic acid sodium |
| 5,7-Dichloroquinurenic acid |
| 5,7-Dichlor-4-hydroxy-chinolin-2-carbonsaeure |
