Introduction：Basic information about CAS 136656-07-0|Timosaponin BII, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Timosaponin BII |
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| CAS Number | 136656-07-0 | Molecular Weight | 921.073 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 1033.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C45H76O19 | Melting Point | / |
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| MSDS | / | Flash Point | 578.9±34.3 °C |
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Names
| Name | Timosaponin B II |
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| Synonym | More Synonyms |
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Timosaponin BII BiologicalActivity
| Description | Timosaponin BII is an antioxidant and an anti-inflammatory agent. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologyNatural Products >>Saccharides and Glycosides |
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| In Vitro | Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1]. |
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| In Vivo | Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2]. |
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| References | [1]. Guo J, et al. Cytotoxic activities of chemical constituents from rhizomes of Anemarrhena asphodeloides and their analogues. Arch Pharm Res. 2015;38(5):598-603. [2]. Huang JF, et al. Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med. 2012 Oct 22;12:189. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 1033.6±65.0 °C at 760 mmHg |
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| Molecular Formula | C45H76O19 |
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| Molecular Weight | 921.073 |
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| Flash Point | 578.9±34.3 °C |
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| Exact Mass | 920.498108 |
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| PSA | 307.37000 |
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| LogP | 0.34 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.627 |
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| InChIKey | SORUXVRKWOHYEO-UJDJZYEZSA-N |
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| SMILES | CC(CCC1(O)OC2CC3C4CCC5CC(OC6OC(CO)C(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C2C1C)COC1OC(CO)C(O)C(O)C1O |
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Synonyms
| (3β,5β,25S)-26-(β-D-Glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside |
| Timosaponinb-II |
| β-D-Galactopyranoside, (3β,5β,25S)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurostan-3-yl 2-O-β-D-glucopyranosyl- |
| N1929 |
| Timosaponin B2 |
