CAS 131189-57-6|Cornuside
| Common Name | Cornuside | ||
|---|---|---|---|
| CAS Number | 131189-57-6 | Molecular Weight | 542.487 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 817.6±65.0 °C at 760 mmHg |
| Molecular Formula | C24H30O14 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 274.5±27.8 °C |
Names
| Name | methyl (2R,3S,4R)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate |
|---|---|
| Synonym | More Synonyms |
Cornuside BiologicalActivity
| Description | Cornuside is a secoiridoid glucoside isolated from the fruit of Cornus officinalis Sieb. et Zucc., which is a traditional oriental medicine for treating inflammatory diseases and invigorating blood circulation. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Cornuside has anti-allergic effects in vivo and in vitro which suggests a therapeutic application of this agent in inflammatory allergic diseases[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/Immunology |
| Target | p38 MAP kinase NF-κB |
| References | [1]. Li L, et al. Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-κB signaling pathways. Biochem Biophys Res Commun. 2016 Apr 29;473(2):408-14. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 817.6±65.0 °C at 760 mmHg |
| Molecular Formula | C24H30O14 |
| Molecular Weight | 542.487 |
| Flash Point | 274.5±27.8 °C |
| Exact Mass | 542.163574 |
| PSA | 221.90000 |
| LogP | -0.31 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.648 |
| InChIKey | SMTKSCGLXONVGL-ZEIULZLQSA-N |
| SMILES | C=CC1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)OC)C1CCOC(=O)c1cc(O)c(O)c(O)c1 |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles10
More Articles| [Optimization of microwave-assisted extraction with RSM and HPLC determination for three iridoid glycosides in Cornus officinalis]. Zhong Yao Cai 34(7) , 1118-22, (2011) To establish a method of microwave-assisted extraction and high performance liquid chromatographic (HPLC) for simultaneous determination of three iridoid glycosides including loganin, sweroside and co... | |
| Simultaneous determination of six active components in crude and processed Fructus Corni by high performance liquid chromatography. J. Pharm. Biomed. Anal. 48(1) , 194-7, (2008) A simple and rapid HPLC method was established for simultaneously determining six active components in Fructus Corni. The six components were separated on an Agilent Zorbax Extend C18 column (250 mmx4... | |
| [Studies on the chemical constituents of Cornus officinalis Sieb et Zucc]. Yao Xue Xue Bao 27(11) , 845-8, (1992) A new bisiridoid glucoside named cornuside was isolated from the fruits of Cornus officinalis Sieb et Zucc. The structure of cornuside has been established by spectroscopic methods (IR, MS, 1HNMR, 13C... |
Synonyms
| Y0054 |
| N1926 |
| 2H-Pyran-5-carboxylic acid, 3-ethenyl-2-(β-D-glucopyranosyloxy)-3,4-dihydro-4-[2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl]-, methyl ester, (2R,3S,4R)- |
| Cornuside |
| Methyl (2R,3S,4R)-2-(β-D-glucopyranosyloxy)-4-{2-[(3,4,5-trihydroxybenzoyl)oxy]ethyl}-3-vinyl-3,4-dihydro-2H-pyran-5-carboxylate |
