Introduction：Basic information about CAS 13957-31-8|4-thiouridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
4-Thiouridine is a ribonucleoside analog, it is widely used in RNA analysis and (m)RNA labeling. 4-Thiouridine inhibits rRNA synthesis and causes a nucleolar stress response[1].
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In Vitro
4-thiouridine (0-10 μM) labels and purifies nascent rRNA without significantly affecting rRNA synthesis[1]. 4-thiouridine (≥50 μM) strongly inhibits production and processing of rRNA[1].
References
[1]. Burger K, et al. 4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response. RNA Biol. 2013 Oct;10(10):1623-30.
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