Introduction：Basic information about CAS 1341-23-7|Nicotinamide Riboside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nicotinamide Riboside |
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| CAS Number | 1341-23-7 | Molecular Weight | 255.247 |
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| Density | 1.201g/cm3 | Boiling Point | 353.7ºC at 760mmHg |
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| Molecular Formula | C11H15N2O5 | Melting Point | / |
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| MSDS | / | Flash Point | 181.9ºC |
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Names
| Name | N-ribosylnicotinamide |
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| Synonym | More Synonyms |
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Nicotinamide Riboside BiologicalActivity
| Description | Nicotinamide riboside is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside is used in dietary supplements[1]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>SirtuinSignaling Pathways >>Cell Cycle/DNA Damage >>Sirtuin |
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| Target | SIRT1 SIRT3 |
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| In Vitro | Nicotinamide riboside (0.5 nM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2[1]. Western Blot Analysis[1] Cell Line: HEK293T cells Concentration: 0.5 nM Incubation Time: 24 hours Result: Reduced the acetylation status of Ndufa9 and SOD2. |
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| In Vivo | Chronic Nicotinamide riboside (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD[+] content in a tissue-specific manner[1]. Animal Model: 10-week-old C57Bl/6J mice[1] Dosage: 400 mg/kg Administration: p.o.; daily; for 16 weeks Result: Increased plasma and intracellular NAD[+] content in a tissue-specific manner. |
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| References | [1]. Cantó C, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protectsagainst high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. |
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Chemical & Physical Properties
| Density | 1.201g/cm3 |
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| Boiling Point | 353.7ºC at 760mmHg |
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| Molecular Formula | C11H15N2O5 |
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| Molecular Weight | 255.247 |
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| Flash Point | 181.9ºC |
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| Exact Mass | 255.097549 |
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| PSA | 116.25000 |
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| LogP | -2.30 |
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| Vapour Pressure | 3.05E-07mmHg at 25°C |
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| Index of Refraction | 1.549 |
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| InChIKey | JLEBZPBDRKPWTD-TURQNECASA-O |
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| SMILES | NC(=O)c1ccc[n+](C2OC(CO)C(O)C2O)c1 |
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Safety Information
Synonyms
| Pyridinium, 3-(aminocarbonyl)-1-β-D-ribofuranosyl- |
| Nicotinamide riboside-oxidized form |
| 3-Carbamoyl-1-(β-D-ribofuranosyl)pyridinium |
| Nicotinamide Ribose |
| 3-(Aminocarbonyl)-1beta-D-ribofuranosylpyridinium |
| 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridine-5-carboxamide |
| NRH-oxidized form |
| 3-(aminocarbonyl)-1-β-D-ribofuranosyl-Pyridinium |
| Nicotinamide riboside |
| N-ribosylnicotinamid |
