CAS 138-39-6|Mafenide

Introduction：Basic information about CAS 138-39-6|Mafenide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Mafenide BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Mafenide
CAS Number	138-39-6	Molecular Weight	186.232
Density	1.3±0.1 g/cm3	Boiling Point	382.0±44.0 °C at 760 mmHg
Molecular Formula	C₇H₁₀N₂O₂S	Melting Point	177-178℃ (decomposition)
MSDS	/	Flash Point	184.8±28.4 °C

Names

Name	4-Aminomethylbenzenesulfonamide
Synonym	More Synonyms

Mafenide BiologicalActivity

Description	Mafenide is a sulfonamide-type medication.Target: AntibacterialMafenide is a sulfonamide-type medication. Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns. It is used to treat severe burns. It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns [1-3].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Siuda, J.F. and C.D. Cihonski, New compounds: carbamate derivatives of mafenide (homosulfanilamide). J Pharm Sci, 1972. 61(11): p. 1856-7. [2]. Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284(23): p. 1324. [3]. Haik, J., et al., Burn care standards in Israel: lack of consensus. Burns, 2005. 31(7): p. 845-9.

Description

Mafenide is a sulfonamide-type medication.Target: AntibacterialMafenide is a sulfonamide-type medication. Mafenide works by reducing the bacterial population present in the avascular tissues of burns and permits spontaneous healing of deep partial-thickness burns. It is used to treat severe burns. It is used topically as an adjunctive therapy for second- and third-degree burns. It is bacteriostatic against many gram-positive and gram-negative organisms, including Pseudomonas aeruginosa. Some sources state that mafenide is more appropriate for non-facial burns, while chloramphenicol/prednisolone or bacitracin are more appropriate for facial burns [1-3].

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

References

[1]. Siuda, J.F. and C.D. Cihonski, New compounds: carbamate derivatives of mafenide (homosulfanilamide). J Pharm Sci, 1972. 61(11): p. 1856-7.

[2]. Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284(23): p. 1324.

[3]. Haik, J., et al., Burn care standards in Israel: lack of consensus. Burns, 2005. 31(7): p. 845-9.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	382.0±44.0 °C at 760 mmHg
Melting Point	177-178℃ (decomposition)
Molecular Formula	C₇H₁₀N₂O₂S
Molecular Weight	186.232
Flash Point	184.8±28.4 °C
Exact Mass	186.046295
PSA	94.56000
LogP	-0.80
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.602
InChIKey	TYMRLRRVMHJFTF-UHFFFAOYSA-N
SMILES	NCc1ccc(S(N)(=O)=O)cc1
Storage condition	2-8℃

Safety Information

HS Code	2935009090

Customs

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Synonyms

4-(Aminomethyl)benzenesulfonamide

EINECS 205-326-9

Benzenesulfonamide, 4-(aminomethyl)-

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