CAS 3600-87-1|Desglymidodrine
Introduction：Basic information about CAS 3600-87-1|Desglymidodrine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desglymidodrine | ||
|---|---|---|---|
| CAS Number | 3600-87-1 | Molecular Weight | 197.23100 |
| Density | / | Boiling Point | 364.3ºC at 760mmHg |
| Molecular Formula | C10H15NO3 | Melting Point | 146-150ºC dec. |
| MSDS | / | Flash Point | 174.1ºC |
Names
| Name | 2-Amino-1-(2,5-dimethoxyphenyl)ethanol |
|---|---|
| Synonym | More Synonyms |
Desglymidodrine BiologicalActivity
| Description | Desglymidodrine (ST 1059), the active metabolite of midodrine, is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
| Target | α1A-adrenergic receptor:5.89 (pKi) α1B-adrenergic receptor:5.16 (pKi) rat alpha1D-adrenergic receptor:5.78 (pKi) human α2A-adrenoceptor:5.83 (pKi) |
| In Vitro | Desglymidodrine (ST 1059) (1-1000 μM) affects vein contraction with the pD2 values (negative logarithm of the concentration which causes 50% of the maximum possible effect) of 4.64 (- log mol/L) in dog isolated femoral veins and 4.48 (- log mol/L) in isolated human saphenous veins, respectively[1]. Desglymidodrine (ST 1059) acts on α1A, α1B, α1D in rat and α2A in human adrenoceptor with the pKi values of 5.89, 5.16, 5.78 and 5.83, respectively[2]. |
| References | [1]. K Nakayama, et al. Effects of anisotropine methylbromide (Valpin) and its mixture with sulpyrine on vocalization response and spasm of intestine induced by acetylcholine in dogs. Jpn J Pharmacol. 1972 Apr;22(2):215-20. [2]. Steven ABuckner, et al. ABT-866, a novel α1A-adrenoceptor agonist with antagonist properties at the α1B- and α1D-adrenoceptor subtypes,European Journal of Pharmacology,Volume 449, Issues 1–2,2002,Pages 159-1 |
Chemical & Physical Properties
| Boiling Point | 364.3ºC at 760mmHg |
|---|---|
| Melting Point | 146-150ºC dec. |
| Molecular Formula | C10H15NO3 |
| Molecular Weight | 197.23100 |
| Flash Point | 174.1ºC |
| Exact Mass | 197.10500 |
| PSA | 64.71000 |
| LogP | 1.39620 |
| Index of Refraction | 1.542 |
| InChIKey | VFRCNXKYZVQYLX-UHFFFAOYSA-N |
| SMILES | COc1ccc(OC)c(C(O)CN)c1 |
| Storage condition | -20°C |
Safety Information
| Hazard Codes | Xn |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2922509090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Synonyms
| Midodrine Related Compound A |
| ST 1059 (Desglymidodrine) |
| 2-amino-1-(2,5-dimethoxyphenyl)ethan-1-ol |
| (+/-)-2-amino-1-(2,5-dimethoxyphenyl)ethanol |
| 1-(2',5'-Dimethoxyphenyl)aminoethanol |
| 1-(2',5'-dimethoxyphenyl)-2-aminoethanol |
| de-glymidodrine |
