Introduction：Basic information about CAS 64862-96-0|Ametantrone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ametantrone |
|---|
| CAS Number | 64862-96-0 | Molecular Weight | 412.482 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | 708.8±60.0 °C at 760 mmHg |
|---|
| Molecular Formula | C22H28N4O4 | Melting Point | / |
|---|
| MSDS | / | Flash Point | 382.4±32.9 °C |
|---|
Names
| Name | 1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione |
|---|
| Synonym | More Synonyms |
|---|
Ametantrone BiologicalActivity
| Description | Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
|---|
| References | [1]. Lee CH, et al. Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem Pharmacol. 2012;83(9):1208-1216. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Boiling Point | 708.8±60.0 °C at 760 mmHg |
|---|
| Molecular Formula | C22H28N4O4 |
|---|
| Molecular Weight | 412.482 |
|---|
| Flash Point | 382.4±32.9 °C |
|---|
| Exact Mass | 412.211060 |
|---|
| PSA | 122.72000 |
|---|
| LogP | -0.63 |
|---|
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
|---|
| Index of Refraction | 1.672 |
|---|
| InChIKey | FFGSXKJJVBXWCY-UHFFFAOYSA-N |
|---|
| SMILES | O=C1c2ccccc2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CB5748000
- CHEMICAL NAME :
- Anthraquinone, 1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-
- CAS REGISTRY NUMBER :
- 64862-96-0
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C22-H28-N4-O4
- MOLECULAR WEIGHT :
- 412.54
- WISWESSER LINE NOTATION :
- L C666 BV IVJ DM2M2Q GM2M2Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 160 mg/kg/6W-I
- TOXIC EFFECTS :
- Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
MUTATION DATA - TYPE OF TEST :
- DNA adduct
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 50 umol/L
- REFERENCE :
- RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 47,73,1985
|
Safety Information
Customs
| HS Code | 2922509090 |
|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
| 9,10-ANTHRACENEDIONE, 1,4-BIS((2-((2-HYDROXYETHYL)AMINO)ETHYL)AMINO)- |
| 9,10-Anthracenedione, 1,4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]- |
| Ametantrone |
| 1,4-Bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthraquinone |
