CAS 16893-05-3|Platinum,diamminetetrachloro-, (OC-6-22)-

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TP2485803

CHEMICAL NAME :

Platinum(IV), diamminetetrachloro-, (Z)-

CAS REGISTRY NUMBER :

16893-05-3

LAST UPDATED :

199410

DATA ITEMS CITED :

8

MOLECULAR FORMULA :

Cl4-H6-N2-Pt

MOLECULAR WEIGHT :

370.97

WISWESSER LINE NOTATION :

.PT..Z&2.G4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

22840 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

26820 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :

DNA adduct

TEST SYSTEM :

Mammal - species unspecified Lymphocyte

DOSE/DURATION :

50 umol/L

REFERENCE :

CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 10,27,1975

Cancer Res. 44(5) , 2043-51, (1984)

Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloropla...

Chem. Biol. Interact. 60(2) , 207-15, (1986)

After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magni...

Chem. Biol. Interact. 74(3) , 343-52, (1990)

DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which...