CAS 645-43-2|Guanethidine sulfate

Introduction：Basic information about CAS 645-43-2|Guanethidine sulfate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Guanethidine sulfate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Guanethidine sulfate
CAS Number	645-43-2	Molecular Weight	296.387
Density	/	Boiling Point	345.6ºC at 760 mmHg
Molecular Formula	C₁₀H₂₄N₄O₄S	Melting Point	/
MSDS	/	Flash Point	162.8ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	guanethidine monosulfate
Synonym	More Synonyms

Guanethidine sulfate BiologicalActivity

Description	Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
References	[1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80. [2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43.

Description

Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine.

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease

References

[1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80.

[2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43.

Chemical & Physical Properties

Boiling Point	345.6ºC at 760 mmHg
Molecular Formula	C₁₀H₂₄N₄O₄S
Molecular Weight	296.387
Flash Point	162.8ºC
Exact Mass	296.151825
PSA	148.12000
LogP	2.29240
InChIKey	YUFWAVFNITUSHI-UHFFFAOYSA-N
SMILES	NC(N)=NCCN1CCCCCCC1.O=S(=O)(O)O
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF3150000

CAS REGISTRY NUMBER :: 645-43-2

LAST UPDATED :: 198809

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H22-N4.H2-O4-S

MOLECULAR WEIGHT :: 296.44

WISWESSER LINE NOTATION :: T8NTJ A2MYZUM &S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Human

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,592,1967 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,57,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn: Harmful;
Risk Phrases	R22
Safety Phrases	S25-S36
RIDADR	NONH for all modes of transport
RTECS	MF3150000
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1)

EINECS 211-442-0

Iporal

Guanethidine bisulfate

1-[2-(1-Azocanyl)ethyl]guanidine sulfate

Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (1:1)

2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid

Sanotensin

MFCD00035403

1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1)

1-[2-(Azocan-1-yl)ethyl]guanidine sulfate

Guanethidine Sulfate

Ismelin sulfate

UNII-5UBY8Y002G

Guanetidin sulfate

Guanethidine monosulfate

1-[2-(Azocan-1-yl)ethyl]guanidinsulfat

N-(2-Guanidino ethyl)heptamethylenimine sulfate

1-(2-azocan-1-ylethyl)guanidine sulfate

Ismelin

guanethidine sulphate

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