Introduction：Basic information about CAS 25775-90-0|(Z)-Capsaicin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (Z)-Capsaicin |
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| CAS Number | 25775-90-0 | Molecular Weight | 305.412 |
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| Density | 1.0±0.1 g/cm3 | Boiling Point | 511.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H27NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 263.1±30.1 °C |
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Names
| Name | (Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide |
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| Synonym | More Synonyms |
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(Z)-Capsaicin BiologicalActivity
| Description | (Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>Neurological Disease |
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| Target | TRPV1 receptor[1] |
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| In Vitro | (Z)-Capsaicin is the cis isomer of capsaicin, acting as a TRPV1 agonist. (Z)-Capsaicin may also blocks the neruonal calcium channel[1]. |
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| In Vivo | (Z)-Capsaicin (Zucapsaicin) significantly attenuates nociceptive behavior after oral administration in rats. (Z)-Capsaicin is also tolerated in the primary or recurrent experimental genital herpes simplex virus infection in guinea pigs[1]. |
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| References | [1]. Bourne N, et al. Civamide (cis-capsaicin) for treatment of primary or recurrent experimental genital herpes. Antimicrob Agents Chemother. 1999 Nov;43(11):2685-8. |
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Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
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| Boiling Point | 511.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H27NO3 |
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| Molecular Weight | 305.412 |
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| Flash Point | 263.1±30.1 °C |
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| Exact Mass | 305.199097 |
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| PSA | 58.56000 |
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| LogP | 3.33 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.524 |
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| InChIKey | YKPUWZUDDOIDPM-VURMDHGXSA-N |
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| SMILES | COc1cc(CNC(=O)CCCCC=CC(C)C)ccc1O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RA8540000
- CHEMICAL NAME :
- 6-Nonenamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-, (Z)-
- CAS REGISTRY NUMBER :
- 25775-90-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C18-H27-N-O3
- MOLECULAR WEIGHT :
- 305.46
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 36,2595,1993
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Safety Information
Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| (6Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide |
| cis-8-methyl-N-vanillyl-6-nonenamide |
| (6Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide |
| (Z)-8-Methyl-N-vanillyl-6-noneamide |
| cis-capsaicin |
| Civanex |
| Zucapsaicin |
| Civamide |
| (Z)-N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide |
| (Z)-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide |
| 6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6Z)- |
| (Z)-CAPSAICIN |
