CAS 3615-17-6|2-acetamido-2-deoxy-D-mannose

Introduction：Basic information about CAS 3615-17-6|2-acetamido-2-deoxy-D-mannose, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2-acetamido-2-deoxy-D-mannose BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	2-acetamido-2-deoxy-D-mannose
CAS Number	3615-17-6	Molecular Weight	221.20800
Density	1.423g/cm3	Boiling Point	636.4ºC at 760mmHg
Molecular Formula	C₈H₁₅NO₆	Melting Point	205ºC
MSDS	/	Flash Point	338.7ºC

Names

Name	aldehydo-N-acetyl-D-mannosamine
Synonym	More Synonyms

2-acetamido-2-deoxy-D-mannose BiologicalActivity

Description	N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1].N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively. N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders[2].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101. [2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.

Description

N-Acetyl-D-mannosamine (ManNAc) is an essential precursor of N-acetylneuraminic acid (NeuAc), the specific monomer of bacterial capsular polysialic acid (PA)[1].N-Acetyl-D-mannosamine (ManNAc) can be metabolized by GNE and GlcNAc 2-epimerase (Renin binding protein, RnBP), into ManNAc-6-phosphate and GlcNAc, respectively. N-Acetyl-d-mannosamine (ManNAc) and its derivatives activates hypocretin (HCRT) gene expression in the orexin neurons, providing a potential model for the testing of a therapy for neural disorders[2].

Related Catalog

Research Areas >>Neurological DiseaseSignaling Pathways >>Anti-infection >>Bacterial

References

[1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30;511(1-3):97-101.

[2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep;12(9):764-778.

Chemical & Physical Properties

Density	1.423g/cm3
Boiling Point	636.4ºC at 760mmHg
Melting Point	205ºC
Molecular Formula	C₈H₁₅NO₆
Molecular Weight	221.20800
Flash Point	338.7ºC
Exact Mass	221.09000
PSA	119.25000
Index of Refraction	1.575
InChIKey	OVRNDRQMDRJTHS-ZTVVOAFPSA-N
SMILES	CC(=O)NC1C(O)OC(CO)C(O)C1O
Storage condition	-20°C Freezer

Synonyms

2-Acetamido-2-deoxy-D-mannopyranose Monohydrate

2-acetamido-2-deoxy-D-galacticol

N-((2S,3R,4S,5R)-3,4,5,6-Tetrahydroxy-1-oxohexan-2-yl)acetamide

GalNAc-ol

2-acetamido-2-deoxygalactitol

2-acetamido-2-deoxy-galactose

HPG-Beta2-N1

2-Acetamido-2-deoxy-D-galactitol

N-acetyl-galactosaminitol

MFCD00136044

D-GalNAc-ol

2-acetamido-2-deoxy-D-mannose

N-Acetyl-D-galactosaminitol

N-Acetyl-D-mannosamine Monohydrate

EINECS 222-790-8

2-acetamido-2-deoxy-D-galacitol

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