CAS 362-06-1|2-hydroxyestrone
Introduction：Basic information about CAS 362-06-1|2-hydroxyestrone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-hydroxyestrone | ||
|---|---|---|---|
| CAS Number | 362-06-1 | Molecular Weight | 286.36500 |
| Density | 1.241g/cm3 | Boiling Point | 481.3ºC at 760 mmHg |
| Molecular Formula | C18H22O3 | Melting Point | 199-201ºC |
| MSDS | / | Flash Point | 259ºC |
Names
| Name | 2-hydroxyestrone |
|---|---|
| Synonym | More Synonyms |
2-hydroxyestrone BiologicalActivity
| Description | 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>CancerResearch Areas >>Endocrinology |
| Target | Human Endogenous Metabolite Estrogen receptor |
| In Vitro | 2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells[2]. Cell Proliferation Assay[2] Cell Line: Human breast cancer cell lines MCF-7, MDA-MB-231, and MDA-MB-330 Concentration: 1-1000 nM Incubation Time: 6 days Result: 10 and 100 nM markedly suppressed the growth and proliferation of the cells in the presence of quinalizarin. The tumor cell growth-inhibitory action of the catechol estrogen was neutralized by the presence of 1 nM estradiol. |
| In Vivo | Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.) and 2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups[3]. Animal Model: Female and male Sprague-Dawley rats (6 weeks old)[3] Dosage: 2 mg/kg Administration: Administered i.p. Result: Levels of both 2-OHE1 and 2-OHE1 4SR in rats treated with 2-OHE1 were significantly different between the induced and noninduced groups. |
| References | [1]. H L Bradlow, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep;150 Suppl:S259-65. [2]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25;259(8):4840-5. [3]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec;13(12):1208-13. |
Chemical & Physical Properties
| Density | 1.241g/cm3 |
|---|---|
| Boiling Point | 481.3ºC at 760 mmHg |
| Melting Point | 199-201ºC |
| Molecular Formula | C18H22O3 |
| Molecular Weight | 286.36500 |
| Flash Point | 259ºC |
| Exact Mass | 286.15700 |
| PSA | 57.53000 |
| LogP | 3.52300 |
| Index of Refraction | 1.609 |
| InChIKey | SWINWPBPEKHUOD-JPVZDGGYSA-N |
| SMILES | CC12CCC3c4cc(O)c(O)cc4CCC3C1CCC2=O |
| Storage condition | 2-8°C |
Safety Information
| Hazard Codes | Xi |
|---|
Synonyms
| 3-Methoxypicolinimidamidehydrochloride |
| 3-O-Methyl 17|A-Estradiol |
| 2-hydroxyestron |
| 2-Hydroxyestrone |
