CAS 36455-72-8|α-Zearalenol
Introduction：Basic information about CAS 36455-72-8|α-Zearalenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | α-Zearalenol | ||
|---|---|---|---|
| CAS Number | 36455-72-8 | Molecular Weight | 320.380 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 599.0±50.0 °C at 760 mmHg |
| Molecular Formula | C18H24O5 | Melting Point | 158-161°C |
| MSDS | USA | Flash Point | 217.9±23.6 °C |
| Symbol | GHS07, GHS08 | Signal Word | Danger |
Names
| Name | (2E,7R,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,15,17-tetraen-13-one |
|---|---|
| Synonym | More Synonyms |
α-Zearalenol BiologicalActivity
| Description | α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER),α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Inflammation/Immunology |
| In Vitro | α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC50 of 12.5 μM[1]. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells[2]. α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells[2]. α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations[2]. Cell Proliferation Assay[1] Cell Line: MFC-7 cells Concentration: 6.25 µM-25 µM Incubation Time: 24 hours Result: Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells. Cell Viability Assay[2] Cell Line: Breast cancer cell lines: MCF-7 and MDA-MB231 Concentration: 0.001 μM, 0.1 μM and 10 μM Incubation Time: 24 hours, 48 hours, 72 hours Result: Modified the cell growth in two breast cancer cell lines. Cell Cycle Analysis[2] Cell Line: MCF7 cells, MDA-MB231 cells Concentration: 0.001 μM, 0.1 μM and 10 μM Incubation Time: 72 hours Result: Observed an increase of cells in cell cycle in MCF7 cells. RT-PCR[2] Cell Line: HepG2 cells Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 72 hours Result: Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses. |
| References | [1]. .Tatay E, et al. Estrogenic activity of zearalenone, α-zearalenol and β-zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28(4):239-242. [2]. Marin DE, et al. Cytotoxic and inflammatory effects of individual and combined exposure of HepG2 cells to zearalenone and its metabolites. Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392(8):937-947. [3]. Nittoli AC, et al. Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach. Metabolomics. 2018 Feb 14;14(3):33. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 599.0±50.0 °C at 760 mmHg |
| Melting Point | 158-161°C |
| Molecular Formula | C18H24O5 |
| Molecular Weight | 320.380 |
| Flash Point | 217.9±23.6 °C |
| Exact Mass | 320.162384 |
| PSA | 86.99000 |
| LogP | 4.17 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.549 |
| InChIKey | FPQFYIAXQDXNOR-QDKLYSGJSA-N |
| SMILES | CC1CCCC(O)CCCC=Cc2cc(O)cc(O)c2C(=O)O1 |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H319-H336-H340-H350-H361fd-H371-H373-H412 |
| Precautionary Statements | P201-P260-P280-P301 + P312 + P330-P305 + P351 + P338-P308 + P313 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22-40-52/53-68/20/21/22-36-11-62-48/20-63-46-45 |
| Safety Phrases | 36/37-61-16-45-53 |
| RIDADR | UN 1648 3 / PGII |
| WGK Germany | 3 |
Synonyms
| (3S,7R,11E)-7,14,16-Trihydroxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclotetradecin-1-one |
| 1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-, (3S,7R,11E)- |
| trans-Zearalenol |
| α zearalenol |
| 2,4-Dihydroxy-6-(6α,10-dihydroxy-trans-1-undecenyl)benzoic acid μ-lactone |
| P-1496 |
| cis-Zearalenol |
| Zearalenol |
| a-Zearalenol |
| α-zearalenol |
