Introduction：Basic information about CAS 131-03-3|Rauwolscine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rauwolscine |
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| CAS Number | 131-03-3 | Molecular Weight | 354.443 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 543.0±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H26N2O3 | Melting Point | 270-280ºC |
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| MSDS | / | Flash Point | 282.2±30.1 °C |
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Names
| Name | rauwolscine |
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| Synonym | More Synonyms |
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Rauwolscine BiologicalActivity
| Description | Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| In Vivo | Rauwolscine (0.5 mg/kg, daily) 通过增强细胞凋亡和减少细胞增殖来减少 Balb/c 雌性小鼠的肿瘤生长[1]。 Rauwolscine (i.v., 2.24 mg/kg) 能明显释放大鼠的舔食冲突反应，类似于α受体激动剂 clonidine (0.022 mg/kg) 和benzodiazepine diazepam (0.5 mg/kg)[2]。 |
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| References | [1]. A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155(4):494-504. [2]. S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54(10):PL179-84. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 543.0±50.0 °C at 760 mmHg |
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| Melting Point | 270-280ºC |
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| Molecular Formula | C21H26N2O3 |
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| Molecular Weight | 354.443 |
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| Flash Point | 282.2±30.1 °C |
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| Exact Mass | 354.194336 |
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| PSA | 65.56000 |
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| LogP | 2.20 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.661 |
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| InChIKey | BLGXFZZNTVWLAY-DIRVCLHFSA-N |
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| SMILES | COC(=O)C1C(O)CCC2CN3CCc4c([nH]c5ccccc45)C3CC21 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- ZG1005000
- CHEMICAL NAME :
- 20-alpha-Yohimban-16-beta-carboxylic acid, 17-alpha-hydroxy-, methyl ester
- CAS REGISTRY NUMBER :
- 131-03-3
- LAST UPDATED :
- 198708
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C21-H26-N2-O3
- MOLECULAR WEIGHT :
- 354.49
- WISWESSER LINE NOTATION :
- T F6 D5 C666 EM ON&&TTTJ TQ UVO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,447,1961
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,317,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,447,1961
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | 23/24/25 |
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| Safety Phrases | 22-36/37/39-45 |
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| RIDADR | UN 1544 6.1/PG 2 |
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| Packaging Group | II |
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| Hazard Class | 6.1(a) |
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Synonyms
| isoyohimbine |
| 17a-Hydroxy-20a-yohimban-16b-carboxylic Acid Methyl Ester |
| KEOXIFENE |
| Corynanthidine |
| a-Yohimbine |
| α-Yohimbine |
| EINECS 205-006-9 |
| 20α-Yohimban-16β-carboxylic acid, 17α-hydroxy-, methyl ester (8CI) |
| Rauwolscine |
| RALOXIFENE HCL |
| KEOXIFENE HYDROCHLORIDE |
| Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16β,17α,20α)- |
| Methyl (16β,17α,20α)-17-hydroxyyohimban-16-carboxylate |
