Introduction：Basic information about CAS 16503-32-5|Brevilin A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Brevilin A |
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| CAS Number | 16503-32-5 | Molecular Weight | 346.417 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 494.0±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H26O5 | Melting Point | / |
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| MSDS | / | Flash Point | 216.0±28.8 °C |
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Names
| Name | Brevilin A |
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| Synonym | More Synonyms |
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Brevilin A BiologicalActivity
| Description | Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26[1][2]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>JAKSignaling Pathways >>Epigenetics >>JAKSignaling Pathways >>Stem Cell/Wnt >>JAKSignaling Pathways >>JAK/STAT Signaling >>STATSignaling Pathways >>Autophagy >>Autophagy |
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| Target | IC50: 10.6 µM (STAT3 signaling)[1] |
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| References | [1]. Chen X, et al. Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells. PLoS One. 2013 May 21;8(5):e63697. [2]. You P, et al. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation. Biomed Pharmacother. 2018 Feb;98:619-625. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 494.0±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H26O5 |
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| Molecular Weight | 346.417 |
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| Flash Point | 216.0±28.8 °C |
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| Exact Mass | 346.178009 |
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| PSA | 69.67000 |
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| LogP | 2.98 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.535 |
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| InChIKey | KUPPZVXLWANEJJ-UXPPPGSFSA-N |
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| SMILES | CC=C(C)C(=O)OC1C2C(CC(C)C3C=CC(=O)C31C)OC(=O)C2C |
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Safety Information
Synonyms
| (3S,3aR,4S,4aR,7aR,8R,9aR)-3,4a,8-Trimethyl-2,5-dioxo-2,3,3a,4,4a,5,7a,8,9,9a-decahydroazuleno[6,5-b]furan-4-yl (2Z)-2-methyl-2-butenoate |
| 2-Butenoic acid, 2-methyl-, (3S,3aR,4S,4aR,7aR,8R,9aR)-2,3,3a,4,4a,5,7a,8,9,9a-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester, (2Z)- |
