CAS 66592-89-0|Kevetrin (hydrochloride)

Introduction：Basic information about CAS 66592-89-0|Kevetrin (hydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Kevetrin (hydrochloride) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Kevetrin (hydrochloride)
CAS Number	66592-89-0	Molecular Weight	179.67100
Density	/	Boiling Point	/
Molecular Formula	C₅H₁₀ClN₃S	Melting Point	125-127 ºC
MSDS	/	Flash Point	/

Names

Name	3-cyanopropyl carbamimidothioate,hydrochloride
Synonym	More Synonyms

Kevetrin (hydrochloride) BiologicalActivity

Description	Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.
Related Catalog	Signaling Pathways >>Apoptosis >>MDM-2/p53Research Areas >>Cancer

Description

Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Target：p53in vitro: Kevetrin activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Kevetrin may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. in vivo: Kevetrin has demonstrated potent anti-tumor efficacy against various carcinoma xenograft models: lung, breast, colon, prostate and squamous cell carcinoma, and in a leukemia tumor model. In drug-resistant cell lines, Kevetrin has shown excellent activity, galvanizing the Company to focus on Kevetrin's development potential in this area.

Related Catalog

Signaling Pathways >>Apoptosis >>MDM-2/p53Research Areas >>Cancer

Chemical & Physical Properties

Melting Point	125-127 ºC
Molecular Formula	C₅H₁₀ClN₃S
Molecular Weight	179.67100
Exact Mass	179.02800
PSA	98.96000
LogP	2.51888
Appearance of Characters	white solid
InChIKey	NCXJZJFDQMKRKM-UHFFFAOYSA-N
SMILES	Cl.N#CCCCSC(=N)N
Storage condition	-20℃

Synonyms

Carbamimidothioic acid,3-cyanopropyl ester,hydrochloride(1:1)

UNII-NL6L2371DP

S-(3-cyano-propyl)-isothiourea,hydrochloride

KEVETRIN

Carbamimidothioic acid,3-cyanopropyl ester,monohydrochloride

S-(3-Cyan-propyl)-isothioharnstoff,Hydrochlorid

Kevetrin hydrochloride

4-Isothioureidobutyronitrile hydrochloride

CarbaMiMidothioic acid, 3-cyanopropyl ester, hydrochloride (1:1)

Kevetrin HCl

Kevetrin (hydrochloride)

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