CAS 180384-56-9|N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-

Introduction：Basic information about CAS 180384-56-9|N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameN-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methyl-pyridine-2-sulfonamide
CAS Number180384-56-9Molecular Weight577.57200
Density1.485g/cm3Boiling Point754.5ºC at 760 mmHg
Molecular FormulaC25H23N9O6SMelting Point/
MSDS/Flash Point410.1ºC

Names

NameN-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methylpyridine-2-sulfonamide
SynonymMore Synonyms

BiologicalActivity

DescriptionClazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5].
Related CatalogResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Endothelin Receptor
In VitroClazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3]. Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5].
In VivoClazosentan (10 μM, 0.05 mL/kg, intracisternal injection) inhibits the contractile responses to ET-1 in rats[2]. Clazosentan (10 mg/kg, s.c.) inhibits IL-33-induced hypernociception in mice[4]. Animal Model: Rats[2] Dosage: 10 μM, 0.05 mL/kg Administration: Intracisternal injection Result: Inhibited the contractile responses to ET-1, without preventing SAH-induced upregulation of ET receptors in cerebral arteries.

Chemical & Physical Properties

Density1.485g/cm3
Boiling Point754.5ºC at 760 mmHg
Molecular FormulaC25H23N9O6S
Molecular Weight577.57200
Flash Point410.1ºC
Exact Mass577.14900
PSA208.49000
LogP3.54870
Vapour Pressure6.34E-24mmHg at 25°C
Index of Refraction1.649
InChIKeyLFWCJABOXHSRGC-UHFFFAOYSA-N
SMILESCOc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO

Synonyms

UNII-3DRR0X4728
Clazosentan
CAS 66592-89-0|Kevetrin (hydrochloride)
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