Introduction：Basic information about CAS 61890-25-3|(Rac)-Lanicemine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (Rac)-Lanicemine |
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| CAS Number | 61890-25-3 | Molecular Weight | 198.26400 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C13H14N2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 1-Phenyl-2-(2-pyridinyl)ethanamine |
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| Synonym | More Synonyms |
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(Rac)-Lanicemine BiologicalActivity
| Description | (Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
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| Target | NMDA receptor[1] |
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| In Vivo | Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1] Dosage: 3, 10 or 30 mg/kg Administration: Intraperitoneal Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |
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| References | [1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85. |
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Chemical & Physical Properties
| Molecular Formula | C13H14N2 |
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| Molecular Weight | 198.26400 |
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| Exact Mass | 198.11600 |
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| PSA | 38.91000 |
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| LogP | 3.02440 |
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| InChIKey | FWUQWDCOOWEXRY-UHFFFAOYSA-N |
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| SMILES | NC(Cc1ccccn1)c1ccccc1 |
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Safety Information
Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-phenyl-2-pyridin-2-yl-ethylamine |
| 2-aziridin-1-yl-1-phenyl-ethanol |
