Introduction：Basic information about CAS 137813-35-5|Cyclo [Arg-Gly-Asp-D-Phe-Val], including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cyclo [Arg-Gly-Asp-D-Phe-Val] |
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| CAS Number | 137813-35-5 | Molecular Weight | 574.62900 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H38N8O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | cyclo(arg-gly-asp-d-phe-val) |
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| Synonym | More Synonyms |
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Cyclo [Arg-Gly-Asp-D-Phe-Val] BiologicalActivity
| Description | Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Cytoskeleton >>Integrin |
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| Target | αvβ3[1] |
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| In Vitro | Cyclo(Arg-Gly-Asp-d-Phe-Val) (c(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1]. Cell Cycle Analysis[1] Cell Line: MV4–11 cells Concentration: 35 nM Incubation Time: 24 h Result: Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems. Apoptosis Analysis[1] Cell Line: MV4–11 cells Concentration: 35 nM Incubation Time: 24 h Result: Increased the apoptosis rates. |
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Chemical & Physical Properties
| Molecular Formula | C26H38N8O7 |
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| Molecular Weight | 574.62900 |
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| Exact Mass | 574.28600 |
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| PSA | 244.70000 |
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| LogP | 0.52700 |
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| InChIKey | YYQUWEHEBOMRPH-NYUBLWNDSA-N |
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| SMILES | CC(C)C1NC(=O)C(Cc2ccccc2)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(CCCN=C(N)N)NC1=O |
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Synonyms
| RGDFV PEPTIDE,CYCLIC |
| Cyclo(Arg-Gly-Asp-D-Phe-Val) |
