CAS 61370-87-4|TYR-D-ALA-GLY-PHE-MET

Introduction：Basic information about CAS 61370-87-4|TYR-D-ALA-GLY-PHE-MET, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameTYR-D-ALA-GLY-PHE-MET
CAS Number61370-87-4Molecular Weight587.68800
Density1.305g/cm3Boiling Point1043.8ºC at 760 mmHg
Molecular FormulaC28H37N5O7SMelting Point/
MSDS/Flash Point585.1ºC

Names

Name(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
SynonymMore Synonyms

TYR-D-ALA-GLY-PHE-MET BiologicalActivity

Description[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].
Related CatalogSignaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease
In Vivo[D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice[1]. Animal Model: Lactating rats[1] Dosage: 0.01, 0.1 and 1 μg Administration: Intracerebroventrical injection Result: Inhibited ACh-induced and suckling-induced OT release.
References

[1]. Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8.

[2]. Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51.

Chemical & Physical Properties

Density1.305g/cm3
Boiling Point1043.8ºC at 760 mmHg
Molecular FormulaC28H37N5O7S
Molecular Weight587.68800
Flash Point585.1ºC
Exact Mass587.24100
PSA225.25000
LogP2.19680
Index of Refraction1.602
InChIKeyMHNSNPIYASDSCR-SZOBAZRNSA-N
SMILESCSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(C)NC(=O)C(N)Cc1ccc(O)cc1)C(=O)O

Synonyms

2-Ala-met-enkephalin
Dalmee
DAMET
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