CAS 96426-21-0|H-Gly-Arg-Gly-Asp-Ser-OH
| Common Name | H-Gly-Arg-Gly-Asp-Ser-OH | ||
|---|---|---|---|
| CAS Number | 96426-21-0 | Molecular Weight | 490.46800 |
| Density | 1.66 g/cm3 | Boiling Point | / |
| Molecular Formula | C17H30N8O9 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | gly-arg-gly-asp-ser |
|---|---|
| Synonym | More Synonyms |
H-Gly-Arg-Gly-Asp-Ser-OH BiologicalActivity
| Description | Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>OthersPeptides |
| In Vitro | Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM[1]. GRGDS-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation[2]. |
| References | [1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997. [2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9. |
Chemical & Physical Properties
| Density | 1.66 g/cm3 |
|---|---|
| Molecular Formula | C17H30N8O9 |
| Molecular Weight | 490.46800 |
| Exact Mass | 490.21400 |
| PSA | 299.15000 |
| Index of Refraction | 1.664 |
| InChIKey | RGNVSYKVCGAEHK-GUBZILKMSA-N |
| SMILES | NCC(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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Synonyms
| Gly-Arg-Gly-Asp-Ser-OH |
| GRGDS 1/2ACOH 2H2O |
| H-GLY-ARG-GLY-ASP-SER-OH |
| GRGDS |
| GRGDS,FIBRONECTIN ATTACHMENT PEPTIDE |
| glycyl-arginyl-glycyl-aspartyl-serine |
| MFCD00076459 |
| L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl |
