CAS 5817-39-0|3,3',5'-triiodothyronine
| Common Name | 3,3',5'-triiodothyronine | ||
|---|---|---|---|
| CAS Number | 5817-39-0 | Molecular Weight | 650.974 |
| Density | 2.4±0.1 g/cm3 | Boiling Point | 534.6±50.0 °C at 760 mmHg |
| Molecular Formula | C15H12I3NO4 | Melting Point | 234-238ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 277.1±30.1 °C |
| Symbol | GHS02, GHS06, GHS08 | Signal Word | Danger |
Names
| Name | 3,3',5'-triiodothyronine |
|---|---|
| Synonym | More Synonyms |
3,3',5'-triiodothyronine BiologicalActivity
| Description | Reverse T3 is a thyroid hormone generated by deiodination of the prohormone thyroxine[1]. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes[2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Thyroid Hormone Receptor |
| References | [1]. Nicod P, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results. J Clin Endocrinol Metab. 1976 May;42(5):823-9. [2]. Rebolledo RA, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats. PLoS One. 2015 Oct 5;10(10):e0138749. |
Chemical & Physical Properties
| Density | 2.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 534.6±50.0 °C at 760 mmHg |
| Melting Point | 234-238ºC(lit.) |
| Molecular Formula | C15H12I3NO4 |
| Molecular Weight | 650.974 |
| Flash Point | 277.1±30.1 °C |
| Exact Mass | 650.790039 |
| PSA | 92.78000 |
| LogP | 5.39 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.763 |
| InChIKey | HZCBWYNLGPIQRK-LBPRGKRZSA-N |
| SMILES | NC(Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O |
| Storage condition | 2-8°C |
Safety Information
| Symbol | GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 36 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | AY6750000 |
| HS Code | 2922509090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles34
More Articles| Postnatal overnutrition programs the thyroid hormone metabolism and function in adulthood. J. Endocrinol. 226 , 219-26, (2015) Early overnutrition (EO) during lactation leads to obesity, leptin resistance and lower thyroid hormone (TH) levels during adulthood. To better understand the biological significance of this thyroid h... | |
| Heredity and lifestyle in the determination of between-subject variation in thyroid hormone levels in euthyroid men. Eur. J. Endocrinol. 169(6) , 835-44, (2013) Variation in thyroid hormone (TH) concentrations between subjects is greater than in a single subject over a prolonged period of time, suggesting an individual set point for thyroid function. We have ... | |
| Halogenated phenolic contaminants inhibit the in vitro activity of the thyroid-regulating deiodinases in human liver. Toxicol. Sci. 124(2) , 339-47, (2011) Halogenated contaminants, particularly brominated flame retardants, disrupt circulating levels of thyroid hormones (THs), potentially affecting growth and development. Disruption may be mediated by im... |
Synonyms
| (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid |
| 3,3',5'-Triiodo-L-thyronine |
| Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3-iodo- |
| Reverse triiodothyronine |
| REVERSE T3 |
| O-(4-Hydroxy-3,5-diiodophenyl)-3-iodotyrosine |
