CAS 25392-41-0|4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one

Introduction：Basic information about CAS 25392-41-0|4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one
CAS Number	25392-41-0	Molecular Weight	210.614
Density	1.4±0.1 g/cm3	Boiling Point	409.6±45.0 °C at 760 mmHg
Molecular Formula	C₁₀H₇ClO₃	Melting Point	180-183ºC
MSDS	/	Flash Point	201.5±28.7 °C

Names

Name	4-(chloromethyl)-7-hydroxychromen-2-one
Synonym	More Synonyms

BiologicalActivity

Description	4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>Others
References	[1]. Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783. [2]. Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19):5892-5896.

Description

4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Others >>Others

References

[1]. Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783.

[2]. Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19):5892-5896.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	409.6±45.0 °C at 760 mmHg
Melting Point	180-183ºC
Molecular Formula	C₁₀H₇ClO₃
Molecular Weight	210.614
Flash Point	201.5±28.7 °C
Exact Mass	210.008377
PSA	50.44000
LogP	2.38
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.619
InChIKey	TXSLBPGPBNGHRW-UHFFFAOYSA-N
SMILES	O=c1cc(CCl)c2ccc(O)cc2o1
Storage condition	2-8℃

Safety Information

Hazard Codes	Xi
HS Code	2932209090

Customs

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

2H-1-Benzopyran-2-one, 4-(chloromethyl)-7-hydroxy-

4-Chloromethyl-7-hydroxychromen-2-one

6-hydroxy-1-chloromethyl-3-oxo-3H-benzopyran

4-(chloromethyl)-7-hydroxy-2H-2-chromenone

4-(chloromethyl)-7-hydroxy-2H-chrome-2-one

chloromethylhydroxychromenone

4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one

CellHunt Blue CMHC [4-Chloromethyl-7-hydroxycoumarin]

4-(Chloromethyl)-7-hydroxycoumarin

7-hydroxy-4-chloromethylcoumarin

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