CAS 342-69-8|Inosine,6-S-methyl-6-thio-
Introduction：Basic information about CAS 342-69-8|Inosine,6-S-methyl-6-thio-, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Inosine,6-S-methyl-6-thio- | ||
|---|---|---|---|
| CAS Number | 342-69-8 | Molecular Weight | 298.32 |
| Density | 1.85g/cm3 | Boiling Point | 636.3ºC at 760mmHg |
| Molecular Formula | C11H14N4O4S | Melting Point | 166°C |
| MSDS | ChineseUSA | Flash Point | 338.6ºC |
Names
| Name | 6-methylthioinosine |
|---|---|
| Synonym | More Synonyms |
Inosine,6-S-methyl-6-thio- BiologicalActivity
| Description | 6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/Analog |
| References | [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. |
Chemical & Physical Properties
| Density | 1.85g/cm3 |
|---|---|
| Boiling Point | 636.3ºC at 760mmHg |
| Melting Point | 166°C |
| Molecular Formula | C11H14N4O4S |
| Molecular Weight | 298.32 |
| Flash Point | 338.6ºC |
| Exact Mass | 298.07400 |
| PSA | 138.82000 |
| Index of Refraction | 1.822 |
| InChIKey | ZDRFDHHANOYUTE-IOSLPCCCSA-N |
| SMILES | CSc1ncnc2c1ncn2C1OC(CO)C(O)C1O |
| Storage condition | −20°C |
| Stability | Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 137 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 44 mg/kg/7W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 780 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - adrenal cortex tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 65 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 3 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,1587,1983
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 3 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,1587,1983
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UO8985000 |
| HS Code | 29349990 |
Articles27
More Articles| The role of inosine-5'-monophosphate dehydrogenase in thiopurine metabolism in patients with inflammatory bowel disease. Ther. Drug Monit. 33 , 200-208, (2011) There is a large interindividual variability in thiopurine metabolism. High concentrations of methylthioinosine-5'-monophosphate (meTIMP) and low concentrations of 6-thioguanine nucleotides (6-TGNs) h... | |
| Methylthioadenosine deaminase in an alternative quorum sensing pathway in Pseudomonas aeruginosa. Biochemistry 51(45) , 9094-103, (2012) Pseudomonas aeruginosa possesses an unusual pathway for 5'-methylthioadenosine (MTA) metabolism involving deamination to 5'-methylthioinosine (MTI) followed by N-ribosyl phosphorolysis to hypoxanthine... | |
| A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis. Scand. J. Gastroenterol. 40(10) , 1205-13, (2005) 6-thioguanine (6-TG) has emerged as a promising therapeutic alternative in patients with Crohn's disease intolerant or resistant to azathioprine (AZA) and/or 6-mercaptopurine (6-MP). The aim of the pr... |
Synonyms
| EINECS 206-442-2 |
| 6-MethylmercaptopurineRiboside |
| MFCD00022826 |
| 6-Methylthioinosine |
| METHYLTHIOINOSINE |
| 6-Methylmercaptopurinribosid |
| 6-methylmp-riboside |
| 6-MMPR |
| 6-METHYLTHIOPURINE RIBOSIDE |
| 6-Methylmercaptopurine riboside |
