CAS 36940-87-1|2'-O-Succinyl-cAMP
| Common Name | 2'-O-Succinyl-cAMP | ||
|---|---|---|---|
| CAS Number | 36940-87-1 | Molecular Weight | 429.27900 |
| Density | 2.16g/cm3 | Boiling Point | 781.3ºC at 760mmHg |
| Molecular Formula | C14H16N5O9P | Melting Point | / |
| MSDS | USA | Flash Point | 426.3ºC |
Names
| Name | 2'-o-monosuccinyladenosine 3':5'-cyclic monophosphate |
|---|---|
| Synonym | More Synonyms |
2'-O-Succinyl-cAMP BiologicalActivity
| Description | 2'-O-Succinyl-cAMP is a cAMP analog that can be covalently coupled to acetylcholinesterase. 2'-O-Succinyl-cAMP conjugate has been used as tracers in a classical heterogeneous competitive enzyme immunoassay allowing the determination of cAMP[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Pradelles P, et, al. Enzyme immunoassays of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate using acetylcholinesterase. Anal Chem. 1989 Mar 1;61(5):447-53. [2]. Luttrell BM, et, al. Reaction coupling of chelation and antigen binding in the calcium ion-dependent antibody binding of cyclic AMP. J Biol Chem. 1991 Nov 15;266(32):21626-30. |
Chemical & Physical Properties
| Density | 2.16g/cm3 |
|---|---|
| Boiling Point | 781.3ºC at 760mmHg |
| Molecular Formula | C14H16N5O9P |
| Molecular Weight | 429.27900 |
| Flash Point | 426.3ºC |
| Exact Mass | 429.06900 |
| PSA | 208.02000 |
| LogP | 0.17950 |
| Index of Refraction | 1.849 |
| InChIKey | QNPSLGPIZRJDAN-UISLRAPISA-N |
| SMILES | Nc1ncnc2c1ncn2C1OC2COP(=O)(O)OC2C1OC(=O)CCC(=O)O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles6
More Articles| Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. Endocrinology 151 , 2151-2161, (2010) In the adrenal cortex, the biosynthesis of steroid hormones is controlled by the pituitary-derived hormone ACTH. The functions of ACTH are principally relayed by activating cAMP-dependent signaling pa... | |
| Different role of cAMP dependent protein kinase and CaMKII in H3 receptor regulation of histamine synthesis and release Neuroscience 164 , 1244-1251, (2009) Histamine H3 autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca2+/CaMKII transduction pathways mediate ... | |
| A real-time fluorescent assay of the purified nitric oxide receptor, guanylyl cyclase. Anal. Biochem. 402 , 129-136, (2010) Nitric oxide (NO) mediates intercellular signaling through activation of its receptor, soluble guanylyl cyclase (sGC), leading to elevation of intracellular guanosine 3',5'-cyclic monophosphate (cGMP)... |
Synonyms
| Adenosine 3',5'-phosphoric acid 2'-hydrogen butanedioate |
| 2'-O-MONOSUCCINYLADENOSINE 3':5'-*CYCLIC MONOPHOSPH |
| succinyladenosine 3',5'-cyclic monophosphate |
