CAS 162558-52-3|MQAE
| Common Name | MQAE | ||
|---|---|---|---|
| CAS Number | 162558-52-3 | Molecular Weight | 326.18600 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H16BrNO3 | Melting Point | 177-179ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide |
|---|---|
| Synonym | More Synonyms |
MQAE BiologicalActivity
| Description | MQAE is a fluorescent indicator that is quenched via collision with chloride, and is more sensitive and selective than 36Cl and microelectrode-based methods for chloride measurement in cells. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersDye ReagentsResearch Areas >>Others |
| In Vitro | Bath-applied to acute brain slices, MQAE provides high-quality labeling of neuronal cells and their processes[1]. MQAE fluorescence is adequate and comparable method for measuring cAMP-dependent chloride transport in individual cells[2]. MQAE can be used to measure intracellular chloride concentration in primary cultures of rat aortic smooth muscle cells (VSMC)[3]. |
| References | [1]. Kovalchuk Y, et al. Two-photon chloride imaging using MQAE in vitro and in vivo. Cold Spring Harb Protoc. 2012 Jul 1;2012(7):778-85. [2]. Andersson C, et al. Determination of chloride efflux by X-ray microanalysis versus MQAE-fluorescence. Microsc Res Tech. 2002 Dec 15;59(6):531-5. [3]. Koncz C, et al. Use of MQAE for measurement of intracellular [Cl-] in cultured aortic smooth muscle cells. Am J Physiol. 1994 Dec;267(6 Pt 2):H2114-23. |
Chemical & Physical Properties
| Melting Point | 177-179ºC(lit.) |
|---|---|
| Molecular Formula | C14H16BrNO3 |
| Molecular Weight | 326.18600 |
| Exact Mass | 325.03100 |
| PSA | 39.41000 |
| InChIKey | DSLLHVISNOIYHR-UHFFFAOYSA-M |
| SMILES | CCOC(=O)C[n+]1cccc2cc(OC)ccc21.[Br-] |
| Storage condition | -20℃ |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933499090 |
Customs
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles13
More Articles| Synthesis and characterization of improved chloride-sensitive fluorescent indicators for biological applications. Anal. Biochem. 178 , 355, (1989) A class of N-substituted quinoline compounds has been introduced recently for the fluorescence measurement of Cl concentration in biological preparations. The most Cl-sensitive compound was 6-methoxy-... | |
| Hypoxia inhibits colonic ion transport via activation of AMP kinase. Ann. Surg. 254 , 957-963, (2011) Mucosal hypoxia is a common endpoint for many pathological processes including ischemic colitis, colonic obstruction and anastomotic failure. Previous studies suggest that hypoxia modulates colonic mu... | |
| The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 50 , 861-870, (2009) TGR5 (Gpbar-1) is a plasma membrane-bound, G protein-coupled receptor for bile acids. TGR5 messenger RNA (mRNA) has been detected in many tissues, including rat cholangiocytes and mouse gallbladder. A... |
Synonyms
| (6-Methoxyquinolinio)acetic acid ethyl ester bromide,MQAE |
| (6-Methoxyquinolinio)acetic acid ethyl ester bromide MQAE |
| ethyl 2-(6-methoxyquinolin-1-ium-1-yl)acetate,bromide |
| MQAE |
