CAS 168982-69-2|N-3-oxo-dodecanoyl-L-homoserine lactone

Introduction：Basic information about CAS 168982-69-2|N-3-oxo-dodecanoyl-L-homoserine lactone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. N-3-oxo-dodecanoyl-L-homoserine lactone BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	N-3-oxo-dodecanoyl-L-homoserine lactone
CAS Number	168982-69-2	Molecular Weight	297.390
Density	1.1±0.1 g/cm3	Boiling Point	519.4±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₇NO₄	Melting Point	/
MSDS	ChineseUSA	Flash Point	267.9±30.1 °C

Names

Name	3-oxo-N-[(3S)-2-oxooxolan-3-yl]dodecanamide
Synonym	More Synonyms

N-3-oxo-dodecanoyl-L-homoserine lactone BiologicalActivity

Description	N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex[1][2].Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine lactone induces the production of IL-8 in 16HBE human bronchial epithelial cells[3].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Anti-infection >>Bacterial
References	[1]. Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):197-201. [2]. Chambers CE, Visser MB, Schwab U, Sokol PA. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS Microbiol Lett. 2005 Mar 15;244(2):297-304. [3]. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B a

Description

N-3-oxo-dodecanoyl-L-Homoserine lactone (3-oxo-C12-HSL) is a bacterial quorum-sensing signaling molecule produced by P. aeruginosa and strains of the B. cepacia complex[1][2].Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.N-3-oxo-dodecanoyl-L-Homoserine lactone induces the production of IL-8 in 16HBE human bronchial epithelial cells[3].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Anti-infection >>Bacterial

References

[1]. Pearson JP, Gray KM, Passador L, Tucker KD, Eberhard A, Iglewski BH, Greenberg EP. Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):197-201.

[2]. Chambers CE, Visser MB, Schwab U, Sokol PA. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS Microbiol Lett. 2005 Mar 15;244(2):297-304.

[3]. Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B a

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	519.4±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₂₇NO₄
Molecular Weight	297.390
Flash Point	267.9±30.1 °C
Exact Mass	297.194000
PSA	72.47000
LogP	2.02
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.484
InChIKey	PHSRRHGYXQCRPU-AWEZNQCLSA-N
SMILES	CCCCCCCCCC(=O)CC(=O)NC1CCOC1=O
Storage condition	-20°C

Safety Information

Hazard Codes	Xn
HS Code	2932209090

Customs

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Dodecanamide, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-

OHN

3-oxo-C12-HSL

3-oxo-C12-AHL

3-Oxo-N-[(3S)-2-oxotetrahydro-3-furanyl]dodecanamide

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