CHEMICAL IDENTIFICATION - RTECS NUMBER :
- PB0825900
- CHEMICAL NAME :
- Methanesulfonanilide, 4'-(1-hydroxy-2-(isopropylamino)ethyl)-
- CAS REGISTRY NUMBER :
- 3930-20-9
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C12-H20-N2-O3-S
- MOLECULAR WEIGHT :
- 272.40
- WISWESSER LINE NOTATION :
- WS1&MR DYQ1MY1&1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 118 mg/kg/4W-I
- TOXIC EFFECTS :
- Cardiac - EKG changes not diagnostic of specified effects Cardiac - pulse rate Cardiac - change in rate
- REFERENCE :
- PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 68,289,1992
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3429 ug/kg/2D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Cardiac - pulse rate Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,319,1994
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 288 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 26,389,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 14 mg/kg/3D-I
- TOXIC EFFECTS :
- Cardiac - pulse rate increase, without fall in BP Cardiac - pulse rate Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,319,1994
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Multiple routes
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 100 mg/kg/2W-I
- TOXIC EFFECTS :
- Cardiac - other changes
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 107,179,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 790 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 25,145,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 113 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5179095
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