Introduction：Basic information about CAS 610791-05-4|1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER |
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| CAS Number | 610791-05-4 | Molecular Weight | 215.246 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 269.0±33.0 °C at 760 mmHg |
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| Molecular Formula | C10H17NO4 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 116.5±25.4 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | Methyl 1-Boc-azetidine-3-carboxylate |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Methyl 1-Boc-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Boc-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 269.0±33.0 °C at 760 mmHg |
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| Molecular Formula | C10H17NO4 |
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| Molecular Weight | 215.246 |
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| Flash Point | 116.5±25.4 °C |
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| Exact Mass | 215.115753 |
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| PSA | 55.84000 |
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| LogP | 0.73 |
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| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
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| Index of Refraction | 1.481 |
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| InChIKey | SECFRXGVLMVUPD-UHFFFAOYSA-N |
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| SMILES | COC(=O)C1CN(C(=O)OC(C)(C)C)C1 |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1-O-tert-butyl 3-O-methyl azetidine-1,3-dicarboxylate |
| 1-BOC-AZETIDINE-3-CARBOXYLICACIDMETHYLESTER |
