CAS 16502-01-5|Tryptoline

Introduction：Basic information about CAS 16502-01-5|Tryptoline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Tryptoline BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles29
7. Synonyms

Common Name	Tryptoline
CAS Number	16502-01-5	Molecular Weight	172.226
Density	1.2±0.1 g/cm3	Boiling Point	351.6±32.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₂N₂	Melting Point	206-208 °C(lit.)
MSDS	ChineseUSA	Flash Point	166.5±25.1 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	1,2,3,4-tetrahydro-9h-pyrido[3,4-b]indole
Synonym	More Synonyms

Tryptoline BiologicalActivity

Description	Tetrahydro-β-carboline (Tryptoline) is a metabolite of tryptamine, also is a competitive serotonin reuptake inhibitor with an Ki value of 6.1 µM[1].
Related Catalog	Research Areas >>Metabolic DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor
Target	serotonin:6.1 μM (Ki)
In Vivo	Tetrahydro-β-carboline (20 µg; i.c.v.) increases the serotonin levels in the same part of the brain in rats[1]. Animal Model: 180-200g female Sprague-Dawley rats[1] Dosage: 20 µg Administration: Intraventricular injection Result: Increased of serotonin levels in the same part of the brain whereas the monoamine oxidase activity was not altered.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	351.6±32.0 °C at 760 mmHg
Melting Point	206-208 °C(lit.)
Molecular Formula	C₁₁H₁₂N₂
Molecular Weight	172.226
Flash Point	166.5±25.1 °C
Exact Mass	172.100052
PSA	27.82000
LogP	1.33
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.670
InChIKey	CFTOTSJVQRFXOF-UHFFFAOYSA-N
SMILES	c1ccc2c3c([nH]c2c1)CNCC3
Storage condition	Refrigerator

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles29

Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.

J. Chromatogr. A. 1210(1) , 115-20, (2008)

A number of N,N-dialkylated tryptamines show psychoactive properties in man which resulted in a renewed interest in psychopharmacological research. Attempts to manufacture these derivatives are increa...

Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

PLoS ONE 6(8) , e23694, (2011)

The cladoniamides are bis-indole alkaloids isolated from Streptomyces uncialis, a lichen-associated actinomycete strain. The cladoniamides have an unusual, indenotryptoline structure rarely observed a...

A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.

Eur. J. Med. Chem. 46 , 3237-49, (2011)

The in vivo anti-thrombotic activities of amino acid modified tetrahydro-β-carbolines depended upon the proximity of the side chain of the amino acid residue to the carboline-cycle. Based on this prox...

Synonyms

2,3,4,9-Tetrahydro-1H-β-carboline

Tetrahydro-b-carboline

Tetrahydro-β-carboline

1,2,3,4-Tetrahydro-b-carboline

2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-

MFCD00004954

1,2,3,4-Tetrahydro-9H-Pyrido[3,4-B]Indole

Tetrahydro-beta-carboline

Triptoline

Tryptoline

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