CAS 16178-48-6|Adenosine-5'-diphosphate disodium salt
| Common Name | Adenosine-5'-diphosphate disodium salt | ||
|---|---|---|---|
| CAS Number | 16178-48-6 | Molecular Weight | 471.165 |
| Density | / | Boiling Point | 877.7ºC at 760 mmHg |
| Molecular Formula | C10H13N5Na2O10P2 | Melting Point | / |
| MSDS | USA | Flash Point | 484.6ºC |
Names
| Name | Adenosine-5'-diphosphate disodium salt |
|---|---|
| Synonym | More Synonyms |
Adenosine-5'-diphosphate disodium salt BiologicalActivity
| Description | Adenosine 5'-diphosphate disodium is a nucleoside diphosphate. Adenosine 5'-diphosphate disodium is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate disodium is a platelet aggregation agent for hemostasis and the development and extension of arterial thrombosis[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular Disease |
| Target | Human Endogenous Metabolite |
| In Vitro | Adenosine 5'-diphosphate disodium (10 μmol/L) 诱导人血小板聚集以及血小板，B10 细胞和 p2y1 转染细胞中的 [Ca2+]i 的增加[1]。 Adenosine 5'-diphosphate disodium (5 μmol/L) 可提高人血小板和 B10 细胞中 cAMP 的水平[1]。 |
| References | [1]. Hechler B, et al. The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation. Blood. 1998 Jul 1;92(1):152-9. [2]. Arts IC, et al. Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16. |
Chemical & Physical Properties
| Boiling Point | 877.7ºC at 760 mmHg |
|---|---|
| Molecular Formula | C10H13N5Na2O10P2 |
| Molecular Weight | 471.165 |
| Flash Point | 484.6ºC |
| Exact Mass | 470.993317 |
| PSA | 257.88000 |
| InChIKey | ORKSTPSQHZNDSC-IDIVVRGQSA-L |
| SMILES | Nc1ncnc2c1ncn2C1OC(COP(=O)(O)OP(=O)([O-])[O-])C(O)C1O.[Na+].[Na+] |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles5
More Articles| A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography. J. Chromatogr. A. 1360 , 240-7, (2014) Glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of N-methyl-d-glucamine, which renders them good hydrophilicity due ... | |
| Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist. Arterioscler. Thromb. Vasc. Biol. 31 , 416-422, (2011) To investigate whether adenosine diphosphate (ADP)-derived adenosine might inhibit platelet aggregation, especially in the presence of a P2Y₁₂ antagonist, where the effects of ADP at the P2Y₁₂ recepto... | |
| Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation. Br. J. Haematol. 153 , 83-91, (2011) ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+) )(o) ]. Lowering [Ca(2+) ](o) pa... |
Synonyms
| Adenosine 5'-Diphosphate Disodium Salt Hydrate |
| EINECS 240-314-7 |
| adenosine diphosphate sodium salt |
| Adenosine 5′-diphosphate disodium salt |
| 5'-ADP-Na2 |
| Adenosine 5'-diphosphate disodium salt |
| 5'-ADP Na Hydrate |
| Adenosine, 5'-(trihydrogen diphosphate), sodium salt (1:2) |
| Disodium 5'-O-{[(hydroxyphosphinato)oxy]phosphinato}adenosine |
| Adenosine 5‘-diphosphate,disodium salt hydrate |
| MFCD00066635 |
| Adenosine-5'-diphosphatedisodiumsalt |
