CAS 134531-42-3|OBAA

Introduction：Basic information about CAS 134531-42-3|OBAA, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. OBAA BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles2
6. Synonyms

Common Name	OBAA
CAS Number	134531-42-3	Molecular Weight	428.64700
Density	0.974 g/cm3	Boiling Point	550.8ºC at 760 mmHg
Molecular Formula	C₂₈H₄₄O₃	Melting Point	/
MSDS	ChineseUSA	Flash Point	301ºC

Names

Name	2-(3-octadecylbenzoyl)prop-2-enoic acid
Synonym	More Synonyms

OBAA BiologicalActivity

Description	OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM[1][2][3].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisSignaling Pathways >>Metabolic Enzyme/Protease >>PhospholipaseResearch Areas >>Inflammation/Immunology
Target	PLA2:70 nM (IC50)
In Vitro	OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells had disintegrated into apoptotic bodies[1].
In Vivo	The immunologically induced bronchospasm in guinea pigs is significantly and dose-dependently inhibited by OBAA (2.5-7 mg/kg i.v.)[3].
References	[1]. J Y Miao, et al. Inhibitors of phospholipase promote apoptosis of human endothelial cells. J Biochem. 1997 Mar;121(3):612-8. [2]. J Eintracht, et al. Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid. Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):659-66. [3]. T Köhler, et al. Phospholipase A2 inhibition by alkylbenzoylacrylic acids. Biochem Pharmacol. 1992 Aug 18;44(4):805-13.

Chemical & Physical Properties

Density	0.974 g/cm3
Boiling Point	550.8ºC at 760 mmHg
Molecular Formula	C₂₈H₄₄O₃
Molecular Weight	428.64700
Flash Point	301ºC
Exact Mass	428.32900
PSA	54.37000
LogP	8.31410
InChIKey	ZBESASFHIWDSCJ-UHFFFAOYSA-N
SMILES	CCCCCCCCCCCCCCCCCCc1ccc(C(=O)C=CC(=O)O)cc1

Safety Information

RIDADR	NONH for all modes of transport

Articles2

Bile acid modulates transepithelial permeability via the generation of reactive oxygen species in the Caco-2 cell line.

Free Radic. Biol. Med. 39(6) , 769-80, (2005)

The barrier functions in epithelial and endothelial cells seem to be very important for maintaining normal biological homeostasis. However, it is unclear whether or how bile acids affect the epithelia...

Calcium entry in Trypanosoma brucei is regulated by phospholipase A2 and arachidonic acid.

Biochem. J. 336 ( Pt 3) , 659-66, (1998)

In contrast with mammalian cells, little is known about the control of Ca2+ entry into primitive protozoans. Here we report that Ca2+ influx in pathogenic Trypanosoma brucei can be regulated by phosph...

Synonyms

OBAA

4-(4-octadecylphenyl)-4-oxo-2-Butenoic acid 3-(4-octadecyl)benzoylacrylic acid

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