Introduction：Basic information about CAS 498-96-4|Guvacine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Guvacine |
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| CAS Number | 498-96-4 | Molecular Weight | 127.141 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 280.8±35.0 °C at 760 mmHg |
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| Molecular Formula | C6H10ClNO2 | Melting Point | 306 - 309 °C(lit.) |
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| MSDS | / | Flash Point | 123.6±25.9 °C |
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Names
| Name | guvacine |
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| Synonym | More Synonyms |
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Guvacine BiologicalActivity
| Description | Guvacine, an alkaloid found in the nut of Areca catechu, is a potent GABA uptakp inhibitor. Guvacine inhibits rat GAT-1, rat GAT-2 and rat GAT-3 with IC50 values of 39 μM, 58 μM and 378 μM, respectively[1]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>GABA ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>GABA Receptor |
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| Target | IC50: 39 μM (rat GAT-1), 58 μM (rat GAT-2), 378 μM (rat GAT-3), 14 μM (human GAT-1), 119 μM (huam GAT-3) and 1870 μM (human BGT-3)[1] |
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| References | [1]. L A Borden, et al. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 280.8±35.0 °C at 760 mmHg |
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| Melting Point | 306 - 309 °C(lit.) |
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| Molecular Formula | C6H10ClNO2 |
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| Molecular Weight | 127.141 |
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| Flash Point | 123.6±25.9 °C |
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| Exact Mass | 127.063332 |
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| PSA | 49.33000 |
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| LogP | 0.72 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.518 |
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| InChIKey | QTDZOWFRBNTPQR-UHFFFAOYSA-N |
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| SMILES | O=C(O)C1=CCCNC1 |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36 |
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Synonyms
| 1,2,5,6-Tetrahydro-pyridin-3-carbonsaeure |
| 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid |
| 1,2,5,6-tetrahydropyridine-3-carboxylic acid |
| 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE |
| 3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro |
| GUVACINE HYDROCHLORIDE |
| GUVACINE-HCL |
| 1,2,3,6-tetrahydropyridine-5-carboxylic acid |
| 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro- |
| 1,2,5,6-Tetrahydronicotinic acid |
| Guvacine hydrochloride,1,2,5,6-Tetrahydropyridine-3-carboxylicacidhydrochloride |
| Guvacine |
| UNII:41538P325K |
| MFCD00055191 |
| 1,2,5,6-tetrahydro-pyridine-3-carboxylic acid |
