Introduction：Basic information about CAS 31428-61-2|Tiamenidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tiamenidine |
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| CAS Number | 31428-61-2 | Molecular Weight | 215.70 |
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| Density | 1.52g/cm3 | Boiling Point | 305.1ºC at 760mmHg |
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| Molecular Formula | C8H10ClN3S | Melting Point | 152° |
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| MSDS | / | Flash Point | 138.3ºC |
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Names
| Name | N-(2-chloro-4-methylthiophen-3-yl)-4,5-dihydro-1H-imidazol-2-amine |
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| Synonym | More Synonyms |
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Tiamenidine BiologicalActivity
| Description | Tiamenidine (HOE 440) is an orally active α2-adrenergic receptor agonist with antihypertensive effect. Tiamenidine is used as an antihypertensive agent for hypertension research[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | IC50: α2-Adrenergic Receptor[1] |
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| References | [1]. D M Roden, et al. Electrophysiologic and hemodynamic effects of chronic oral therapy with the alpha 2-agonists clonidine and tiamenidine in hypertensive volunteers. Clin Pharmacol Ther. 1988 Jun;43(6):648-54. |
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Chemical & Physical Properties
| Density | 1.52g/cm3 |
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| Boiling Point | 305.1ºC at 760mmHg |
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| Melting Point | 152° |
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| Molecular Formula | C8H10ClN3S |
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| Molecular Weight | 215.70 |
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| Flash Point | 138.3ºC |
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| Exact Mass | 215.02800 |
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| PSA | 64.66000 |
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| LogP | 1.91840 |
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| Index of Refraction | 1.717 |
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| InChIKey | CVWILQHZFWRYPB-UHFFFAOYSA-N |
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| SMILES | Cc1csc(Cl)c1NC1=NCCN1 |
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Hoe-440 |
| Tiamenidinum |
| Hoe-42-440 |
| Tiamenidine |
| Tiamenidina |
