CAS 139-13-9|nitrilotriacetic acid
Introduction：Basic information about CAS 139-13-9|nitrilotriacetic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | nitrilotriacetic acid | ||
|---|---|---|---|
| CAS Number | 139-13-9 | Molecular Weight | 191.139 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 498.2±40.0 °C at 760 mmHg |
| Molecular Formula | C6H9NO6 | Melting Point | 245 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 255.1±27.3 °C |
| Symbol | GHS07, GHS08 | Signal Word | Warning |
Names
| Name | nitrilotriacetic acid |
|---|---|
| Synonym | More Synonyms |
nitrilotriacetic acid BiologicalActivity
| Description | Nitrilotriacetic acid is an aminotricarboxylic acid. Nitrilotriacetic acid can be used as a chelating agent, forming coordination compounds with metal ions[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 498.2±40.0 °C at 760 mmHg |
| Melting Point | 245 °C (dec.)(lit.) |
| Molecular Formula | C6H9NO6 |
| Molecular Weight | 191.139 |
| Flash Point | 255.1±27.3 °C |
| Exact Mass | 191.042984 |
| PSA | 115.14000 |
| LogP | -1.76 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.558 |
| InChIKey | MGFYIUFZLHCRTH-UHFFFAOYSA-N |
| SMILES | O=C(O)CN(CC(=O)O)CC(=O)O |
| Water Solubility | Insoluble. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3160 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 325 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41292 mg/kg/7W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 29439 ug/kg/4W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - changes in calcium
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 430 gm/kg/75W-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 832 gm/kg/66W-C
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors
MUTATION DATA - TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 2 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80058 No. of Facilities: 1115 (estimated) No. of Industries: 31 No. of Occupations: 32 No. of Employees: 13454 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80058 No. of Facilities: 1082 (estimated) No. of Industries: 24 No. of Occupations: 23 No. of Employees: 25216 (estimated) No. of Female Employees: 7169 (estimated)
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Embryo
- DOSE/DURATION :
- 2 gm/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 356,85,1996 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 48,181,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80058 No. of Facilities: 1115 (estimated) No. of Industries: 31 No. of Occupations: 32 No. of Employees: 13454 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80058 No. of Facilities: 1082 (estimated) No. of Industries: 24 No. of Occupations: 23 No. of Employees: 25216 (estimated) No. of Female Employees: 7169 (estimated)
Safety Information
| Symbol | GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H351 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22;R36/37/38;R40 |
| Safety Phrases | S26-S36/37-S45-S36/37/39 |
| RIDADR | 2811 |
| WGK Germany | 2 |
| RTECS | AJ0175000 |
| Packaging Group | II |
| Hazard Class | 8 |
| HS Code | 29224995 |
Customs
| HS Code | 2921199090 |
|---|---|
| Summary | 2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Synonyms
| nitrilotriacetate |
| combretastatin A2 |
| aminotriacetic acid |
| Prochlorperazin |
| MFCD00004287 |
| N,N-Bis(carboxymethyl)glycine,NTA,Tris(carboxymethyl)amine |
| 2,2',2''-Nitrilotriacetic acid |
| tri(carboxymethyl)amine |
| Triglycine |
| Nitrilotriessigsaeure |
| EINECS 205-355-7 |
| Glycine, N,N-bis(carboxymethyl)- |
| nitriloacetate |
| N,N-bis(carboxymethoxy)glycine |
| nitrilotriacetic acid |
| Triglycollamic acid |
| prochlorperazine Maleate |
| Tris(carboxymethyl)amine |
| α,α',α''-Trimethylaminetricarboxylic acid |
| Ntana3 |
| Prochlorperazinemaleat |
| UNII-KA90006V9D |
| N,N-Bis(carb |
| a,a',a''-Trimethylaminetricarboxylic Acid |
| NTA |
| Complexon I |
