Introduction：Basic information about CAS 136310-93-5|Tiotropium bromide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tiotropium bromide |
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| CAS Number | 136310-93-5 | Molecular Weight | 472.416 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C19H22BrNO4S2 | Melting Point | 218-2200C |
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| MSDS | / | Flash Point | / |
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Names
| Name | Tiotropium Bromide |
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| Synonym | More Synonyms |
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Tiotropium bromide BiologicalActivity
| Description | Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mAChRSignaling Pathways >>Neuronal Signaling >>mAChRResearch Areas >>Neurological Disease |
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| Target | mAChR |
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| In Vitro | Tiotropium Bromide stops signaling between neurons and leads to muscle relaxation. Tiotropium Bromide is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. Tiotropium Bromide improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. |
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| References | [1]. Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10(4):733-40. [2]. ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5(8):1827-35. [3]. Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1(2):107-14. [4]. Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3(3):211-20. [5]. Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD)]. Pneumonol Alergol Pol. 2012;80(3):255-62. |
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Chemical & Physical Properties
| Melting Point | 218-2200C |
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| Molecular Formula | C19H22BrNO4S2 |
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| Molecular Weight | 472.416 |
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| Exact Mass | 471.017365 |
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| PSA | 115.54000 |
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| InChIKey | DQHNAVOVODVIMG-RGECMCKFSA-M |
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| SMILES | C[N+]1(C)C2CC(OC(=O)C(O)(c3cccs3)c3cccs3)CC1C1OC12.[Br-] |
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| Storage condition | Refrigerator |
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36:Irritating to the eyes. |
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| Safety Phrases | S23-S24/25 |
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| WGK Germany | 3 |
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| HS Code | 29309070 |
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Customs
Synonyms
| Tiova |
| 3-Oxa-9-azoniatricyclo[3.3.1.0]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide, (1R,2R,4S,5S)- (1:1) |
| MFCD00867027 |
| (1a,2b,4b,5a,7b)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0 2,4 ]nonane bromide |
| BA 679 BR |
| (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide |
| 6b,7b-Epoxy-3b-hydroxy-8-methyl-1aH,5aH-tropanium bromide di-2-thienylglycolate |
| Spiriva Handihaler |
| TIOTROPIUM BROMIDE |
| (1R,2R,4S,5S,7s)-7-[2-Hydroxy(di-2-thienyl)acetoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0]nonane bromide |
| Spiriva |
| Tiotropium (Bromide) |
